5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

Names
IUPAC name (2R,3R,4S,5R)-2-(5,6-Dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Other names DRB
Identifiers
CAS Registry Number	53-85-0 N
ChEMBL	ChEMBL375530 Y
ChemSpider	5683 Y
DrugBank	DB08473 Y
InChI InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 Y Key: XHSQDZXAVJRBMX-DDHJBXDOSA-N Y InChI=1/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 Key: XHSQDZXAVJRBMX-DDHJBXDOBF
Jmol-3D images	Image
PubChem	5894
SMILES Clc2cc1ncn(c1cc2Cl)[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)CO
Properties
Chemical formula	C12H12Cl2N2O4
Molar mass	319.14 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.^[1]

References