4-aminobutyrate—pyruvate transaminase

4-aminobutyrate---pyruvate transaminase
Identifiers
EC number 2.6.1.96
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4-aminobutyrate---pyruvate transaminase (EC 2.6.1.96, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate transaminase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4-aminobutyrate aminotransferase, 4-aminobutyric acid aminotransferase, aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with system name 4-aminobutanoate:pyruvate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) 4-aminobutanoate + pyruvate \rightleftharpoons succinate semialdehyde + L-alanine
(2) 4-aminobutanoate + glyoxylate \rightleftharpoons succinate semialdehyde + glycine

This enzyme requires pyridoxal 5'-phosphate.

References

  1. ↑ Van Cauwenberghe, O.R. and Shelp, B.J. (1999). "Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum". Phytochemistry 52: 575–581. doi:10.1016/s0031-9422(99)00301-5.
  2. ↑ Palanivelu, R., Brass, L., Edlund, A.F. and Preuss, D. (2003). "Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels". Cell 114 (1): 47–59. doi:10.1016/s0092-8674(03)00479-3. PMID 12859897.
  3. ↑ Clark, S.M., Di Leo, R., Dhanoa, P.K., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). "Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis γ-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate". J. Exp. Bot. 60: 1743–1757. doi:10.1093/jxb/erp044. PMID 19264755.
  4. ↑ Clark, S.M., Di Leo, R., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). "Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate". J. Exp. Bot. 60: 3255–3267. doi:10.1093/jxb/erp161. PMID 19470656.

External links