4-Hydroxybutyrate dehydrogenase

4-hydroxybutyrate dehydrogenase
Identifiers
EC number 1.1.1.61
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybutanoate + NAD+ \rightleftharpoons succinate semialdehyde + NADH + H+

The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD+, whereas its 3 products are succinate semialdehyde, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.[1] The systematic name of this enzyme class is 4-hydroxybutanoate:NAD+ oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid.[2]

References

  1. Nirenberg MW and Jakoby WB (1960). "Enzymatic utilization of gamma-hydroxybutyric acid". J. Biol. Chem. 235: 954960. PMID 14427301.
  2. Kaufman EE, Nelson T (1991). "An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway". Neurochem. Res. 16 (9): 965–974. doi:10.1007/BF00965839. PMID 1784339.