3T3-L1

3T3-L1 is a cell line derived from (mouse) 3T3 cells that is used in biological research on adipose tissue. 3T3-L1 cells have a fibroblast-like morphology, but, under appropriate conditions, the cells differentiate into an adipocyte-like phenotype.

3T3-L1 cells of the adipocyte morphology increase the synthesis and accumulation of triglycerides and acquire the signet ring appearance of adipose cells. These cells are also sensitive to lipogenic and lipolytic hormones and drugs, including epinephrine, isoproterenol, and insulin.[1] 3T3-L1 cells are extensively used to study adipogenesis.[2]

Sources

  1. ↑ Green H, Kehinde O (1975). "An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion". Cell 5 (1): 19–27. doi:10.1016/0092-8674(75)90087-2. PMID 165899.
  2. ↑ Atanasov, A. G.; Wang, J. N.; Gu, S. P.; Bu, J; Kramer, M. P.; Baumgartner, L; Fakhrudin, N; Ladurner, A; Malainer, C; Vuorinen, A; Noha, S. M.; Schwaiger, S; Rollinger, J. M.; Schuster, D; Stuppner, H; Dirsch, V. M.; Heiss, E. H. (2013). "Honokiol: A non-adipogenic PPARγ agonist from nature". Biochimica et Biophysica Acta (BBA) - General Subjects 1830 (10): 4813–9. doi:10.1016/j.bbagen.2013.06.021. PMC 3790966. PMID 23811337.