3-Aminoisobutyric acid

3-Aminoisobutyric acid
Names

IUPAC name 3-Amino-2-methylpropanoic acid
Other names 3-Aminoisobutyrate
Identifiers
CAS Registry Number	144-90-1^N
ChEBI	CHEBI:27389^Y
ChemSpider	58481^Y
InChI InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)^Y Key: QCHPKSFMDHPSNR-UHFFFAOYSA-N^Y InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7) Key: QCHPKSFMDHPSNR-UHFFFAOYAN
Jmol-3D images	Image Image
KEGG	C05145^Y
PubChem	64956
SMILES CC(CN)C(=O)O O=C(O)C(C)CN
Properties
Chemical formula	C₄H₉NO₂
Molar mass	103.12 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

3-Aminoisobutyric acid (or β-aminoisobutyric acid, 'BAIBA') is a product formed by the catabolism of thymine.

It has recently been postulated to play a role in cell metabolism, how body burns fat and regulates insulin, triglycerides, and total cholesterol.^[1] During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from exercising muscles to blood (concentration 2 to 3 µM in human serum). When BAIBA reaches the white fat tissue, it activates the expression of thermogenic genes via PPARα receptors, resulting in a browning of white fat cells.^[2] One of the consequences of the BAIBA activity is the increase of the background metabolism of the BAIBA target cells.

Nucleotide metabolic intermediates

Purine metabolism

Anabolism

R5P→IMP:	R5P PRPP PRA GAR FGAR FGAM AIR CAIR SAICAR AICAR FAICAR

IMP→AMP:	Adenylosuccinate

IMP→GMP:	Xanthosine monophosphate

Catabolism

Pyrimidine metabolism

Anabolism

Catabolism

uracil:	Dihydrouracil 3-Ureidopropionic acid β-Alanine

thymine:	Dihydrothymine β-Ureidoisobutyric acid 3-Aminoisobutyric acid

Index of inborn errors of metabolism

Description	Metabolism Enzymes and pathways: citric acid cycle enzymes pentose phosphate intermediates glycoproteins enzymes glycosaminoglycans proteoglycan enzymes phospholipid metabolism cholesterol and steroid intermediates sphingolipids enzymes eicosanoids enzymes amino acid intermediates urea cycle enzymes nucleotide intermediates

Disorders	Citric acid cycle and electron transport chain Glycoprotein Proteoglycan Fatty-acid Phospholipid Cholesterol and steroid Eicosanoid Amino acid Purine-pyrimidine Heme metabolism Symptoms and signs

Treatment	Drugs other

Index of biochemical families

Carbohydrates	Alcohols Glycoproteins Glycosides

Lipids	Eicosanoids Fatty acids intermediates Glycerides Phospholipids Sphingolipids Steroids

Nucleic acids	Constituents intermediates

Proteins	Amino acids intermediates

Other	Tetrapyrroles intermediates

3-Aminoisobutyric acid

References