2-Nitropropane

2-Nitropropane

Names
IUPAC name 2-Nitropropane
Identifiers
Abbreviations	2-NP
CAS Registry Number	79-46-9
ChEBI	CHEBI:16037
ChemSpider	387
EC number	201-209-1
InChI InChI=1S/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3 Key: FGLBSLMDCBOPQK-UHFFFAOYSA-N InChI=1/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3 Key: FGLBSLMDCBOPQK-UHFFFAOYAM
Jmol-3D images	Image
PubChem	398
SMILES CC(C)[N+](=O)[O-]
Properties
Molecular formula	C3H7NO2
Molar mass	89.09 g·mol−1
Appearance	Colorless liquid[1]
Odor	Pleasant, fruity[2]
Density	0.9821 g/cm3
Melting point	−91.3 °C (−132.3 °F; 181.8 K)
Boiling point	120.2 °C (248.4 °F; 393.3 K)
Solubility in water	17 g/L[1]
Solubility	soluble in chloroform
log P	0.93
Acidity (pKa)	7.68
Refractive index (nD)	1.3944 (20 °C)
Viscosity	0.721 cP
Hazards
NFPA 704	3 2
Flash point	24 °C (75 °F; 297 K) (open cup) 39 °C (closed cup)
Autoignition temperature	428 °C (802 °F; 701 K)
LD50 (Median lethal dose)	720 mg/kg
US health exposure limits (NIOSH):
PEL (Permissible)	TWA 25 ppm (90 mg/m3)[3]
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

2-Nitropropane (2-NP) is a solvent. It is a colorless liquid and is classified as a nitro compound.

Preparation

2-NP is produced by the high-temperature vapor-phase nitration of propane, usually with impurities of 1-nitropropane.

Uses

2-NP is used primarily as a solvent and chemical intermediate. It is used in inks, paints, adhesives, varnishes, polymers, resins, fuel, and coatings.^[4]

2-NP is also used as a feedstock for other industrial chemicals.^[4]

2-NP has uses in the synthesis of phentermine, chlorphentermine, as well as in the synthesis of Teclozan, etc.

Safety

Based on studies in animals, 2-NP is reasonably anticipated to be a human carcinogen^[4] and it is listed as an IARC Group 2B carcinogen.^[5]

References