1,2-Dichloropropane

1,2-Dichloropropane^[1]

Names
IUPAC name 1,2-Dichloropropane
Other names Propylene dichloride
Identifiers
CAS Registry Number	78-87-5 Y
ChEMBL	ChEMBL44641 Y
ChemSpider	6316 Y
InChI InChI=1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3 Y Key: KNKRKFALVUDBJE-UHFFFAOYSA-N Y InChI=1/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3 Key: KNKRKFALVUDBJE-UHFFFAOYAR
Jmol-3D images	Image
KEGG	C19034 N
PubChem	6564
SMILES ClCC(Cl)C
UNII	RRZ023OFWL Y
Properties
Molecular formula	C3H6Cl2
Molar mass	112.99 g·mol−1
Appearance	Colorless liquid
Odor	like chloroform
Density	1.156 g/cm3
Melting point	−100 °C (−148 °F; 173 K)
Boiling point	95 °C (203 °F; 368 K)
Solubility in water	0.26 g/100 mL (at 20 °C)
Hazards
R-phrases	R11 R20/22
S-phrases	S16 S24
Flash point	16 °C (61 °F; 289 K)
Autoignition temperature	557 °C (1,035 °F; 830 K)
Explosive limits	3.4%-14.5%[2]
US health exposure limits (NIOSH):
PEL (Permissible)	TWA 75 ppm (350 mg/m3)[2]
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.^[3]

Uses

1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals.^[3] It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.^[4]

Carcinogenity

Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.^[5][6]

Data from animal studies show tumor growth in the liver and mammary glands.^[7] Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.^[8]

References