ZP3

From Wikipedia, the free encyclopedia
Zona pellucida glycoprotein 3 (sperm receptor)

Crystal structure of full-length ZP3[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsZP3; ZP3A; ZP3B; ZPC; Zp-3
External IDsOMIM: 182889 MGI: 99215 HomoloGene: 5178 GeneCards: ZP3 Gene
Orthologs
SpeciesHumanMouse
Entrez778422788
EnsemblENSG00000188372ENSMUSG00000004948
UniProtP21754P10761
RefSeq (mRNA)NM_001110354NM_011776
RefSeq (protein)NP_001103824NP_035906
Location (UCSC)Chr 7:
76.03 – 76.07 Mb		Chr 5:
135.98 – 135.99 Mb
PubMed search
This box:

Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a protein that in humans is encoded by the ZP3 gene.[2][3] ZP3 is the receptor in the zona pellucida which binds sperm at the beginning of fertilization.

Function

The zona pellucida (ZP) is a specialized extracellular matrix that surrounds the oocyte and early embryo. It is composed of three or four glycoproteins (ZP1-4) with various functions during oogenesis, fertilization and preimplantation development. The protein encoded by this gene is a major structural component of the ZP and functions in primary binding and simulation of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site (CFCS), a polymerization-blocking external hydrophobic patch (EHP), and a C-terminal transmembrane domain. Cleavage at the CFCS separates the mature protein from the EHP, allowing it to incorporate into nascent ZP filaments. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.[2]

References

  1. ↑ PDB 3NK3 PDB 3NK4; Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. 
  2. ↑ 2.0 2.1 "Entrez Gene: zona pellucida glycoprotein 3 (sperm receptor)". 
  3. ↑ van Duin M, Polman JE, Verkoelen CC, Bunschoten H, Meyerink JH, Olijve W, Aitken RJ (December 1992). "Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations". Genomics 14 (4): 1064–70. doi:10.1016/S0888-7543(05)80130-2. PMID 1478648. 

Further reading

  • Bansal P, Chakrabarti K, Gupta SK (2009). "Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus". Biol. Reprod. 81 (1): 7–15. doi:10.1095/biolreprod.108.074716. PMID 19246320. 
  • Choudhury S, Ganguly A, Chakrabarti K, et al. (2009). "DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies". J. Reprod. Immunol. 79 (2): 137–47. doi:10.1016/j.jri.2008.09.002. PMID 19004505. 
  • Chiu PC, Wong BS, Chung MK, et al. (2008). "Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa". Biol. Reprod. 79 (5): 869–77. doi:10.1095/biolreprod.108.069344. PMID 18667750. 
  • Gook DA, Edgar DH, Borg J, Martic M (2008). "Detection of zona pellucida proteins during human folliculogenesis". Hum. Reprod. 23 (2): 394–402. doi:10.1093/humrep/dem373. PMID 18033806. 
  • Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature 456 (7222): 653–7. doi:10.1038/nature07599. PMID 19052627.  PDB 3D4C PDB 3D4G PDB 3EF7
  • Törmälä RM, Jääskeläinen M, Lakkakorpi J, et al. (2008). "Zona pellucida components are present in human fetal ovary before follicle formation". Mol. Cell. Endocrinol. 289 (1-2): 10–5. doi:10.1016/j.mce.2008.01.029. PMID 18502569. 
  • Ni Y, Li K, Xu W, et al. (2007). "Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism". J. Androl. 28 (3): 381–8. doi:10.2164/jandrol.106.001289. PMID 17192598. 
  • Caballero-Campo P, Chirinos M, Fan XJ, et al. (2006). "Biological effects of recombinant human zona pellucida proteins on sperm function". Biol. Reprod. 74 (4): 760–8. doi:10.1095/biolreprod.105.047522. PMID 16407501. 
  • Furlong LI, Harris JD, Vazquez-Levin MH (2005). "Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC". Fertil. Steril. 83 (6): 1780–90. doi:10.1016/j.fertnstert.2004.12.042. PMID 15950651. 
  • Wassarman PM, Jovine L, Litscher ES (2001). "A profile of fertilization in mammals". Nat Cell Biol. 3 (2): E59–64. doi:10.1038/35055178. PMID 11175768. 
  • Rankin T, Dean J (2000). "The zona pellucida: using molecular genetics to study the mammalian egg coat". Rev. Reprod. 5 (2): 114–21. doi:10.1530/ror.0.0050114. PMID 10864856. 
  • Chamberlin ME, Dean J (1990). "Human homolog of the mouse sperm receptor". Proc. Natl. Acad. Sci. U.S.A. 87 (16): 6014–8. doi:10.1073/pnas.87.16.6014. PMID 2385582. 
  • Florman HM, Wassarman PM (1985). "O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity". Cell 41 (1): 313–24. doi:10.1016/0092-8674(85)90084-4. PMID 2986849. 
  • Bleil JD, Wassarman PM (1980). "Mammalian sperm-egg interaction: identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm". Cell 20 (3): 873–82. doi:10.1016/0092-8674(80)90334-7. PMID 7418009. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.