ZNF202
From Wikipedia, the free encyclopedia
| Zinc finger protein 202 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ZNF202; ZKSCAN10; ZSCAN42 | ||||||||||||
| External IDs | OMIM: 603430 MGI: 1933401 HomoloGene: 68317 GeneCards: ZNF202 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7753 | 80902 | |||||||||||
| Ensembl | ENSG00000166261 | ENSMUSG00000025602 | |||||||||||
| UniProt | O95125 | E9Q2D3 | |||||||||||
| RefSeq (mRNA) | NM_003455 | NM_030713 | |||||||||||
| RefSeq (protein) | NP_003446 | NP_109638 | |||||||||||
| Location (UCSC) | Chr 11: 123.59 – 123.61 Mb | Chr 9: 40.19 – 40.21 Mb | |||||||||||
| PubMed search | |||||||||||||
Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2] Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.
References
- ↑ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Dec 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
- ↑ "Entrez Gene: ZNF202 zinc finger protein 202".
- Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0.
Further reading
- Scanlan MJ, Gordan JD, Williamson B et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Schumacher C, Wang H, Honer C et al. (2000). "The SCAN domain mediates selective oligomerization". J. Biol. Chem. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
- Wagner S, Hess MA, Ormonde-Hanson P et al. (2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". J. Biol. Chem. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
- Porsch-Ozcurumez M, Langmann T, Heimerl S et al. (2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". J. Biol. Chem. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
- Babb R, Bowen BR (2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". Biochem. J. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG et al. (2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". J. Lipid Res. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.
External links
- ZNF202 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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