YWHAE

From Wikipedia, the free encyclopedia

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

PDB rendering based on 2br9.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2BR9, 3UAL, 3UBW

Identifiers

Symbols

YWHAE; 14-3-3E; KCIP-1; MDCR; MDS

External IDs

OMIM: 605066 MGI: 894689 HomoloGene: 38223 GeneCards: YWHAE Gene

Gene Ontology
Molecular function	• protein binding • enzyme binding • protein domain specific binding • protein complex binding • histone deacetylase binding • phosphoserine binding • phosphoprotein binding
Cellular component	• mitochondrion • cytosol • kinesin complex • cytoplasmic vesicle membrane • axon part • melanosome
Biological process	• G2/M transition of mitotic cell cycle • mitotic cell cycle • neuron migration • protein targeting • apoptotic process • cellular membrane organization • virus-host interaction • hippocampus development • cerebral cortex development • negative regulation of protein dephosphorylation • hippo signaling cascade • intracellular signal transduction • neurotrophin TRK receptor signaling pathway • apoptotic signaling pathway • intrinsic apoptotic signaling pathway • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
1.25 – 1.3 Mb

Chr 11:
75.73 – 75.77 Mb

PubMed search

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.^[1]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.^[2]

Interactions

YWHAE has been shown to interact with CDC25B,^[3]^[4] Insulin-like growth factor 1 receptor,^[5] NGFRAP1,^[6] TGF beta 1,^[7] HERG,^[8] C-Raf,^[4]^[9] NDEL1,^[10] HDAC4,^[11]^[12] IRS1^[5] and MAP3K3.^[13]

References

↑ Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM (December 1997). "Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization". Cytogenet Cell Genet 78 (2): 105–6. doi:10.1159/000134638. PMID 9371399.
↑ "Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide".
↑ Mils, V; Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (March 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene (ENGLAND) 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667. Cite uses deprecated parameters (help)
↑ 4.0 4.1 Conklin, D S; Galaktionov K, Beach D (August 1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. ISSN 0027-8424. PMC 41252. PMID 7644510. Cite uses deprecated parameters (help)
↑ 5.0 5.1 Craparo, A; Freund R, Gustafson T A (April 1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. (UNITED STATES) 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. ISSN 0021-9258. PMID 9111084. Cite uses deprecated parameters (help)
↑ Kimura, M T; Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato T A (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. (United States) 276 (20): 17291–300. doi:10.1074/jbc.M005453200. ISSN 0021-9258. PMID 11278287. Cite uses deprecated parameters (help)
↑ McGonigle, S; Beall M J, Feeney E L, Pearce E J (February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors". FEBS Lett. (Netherlands) 490 (1–2): 65–9. doi:10.1016/S0014-5793(01)02133-0. ISSN 0014-5793. PMID 11172812. Cite uses deprecated parameters (help)
↑ Kagan, Anna; Melman Yonathan F, Krumerman Andrew, McDonald Thomas V (April 2002). "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity". EMBO J. (England) 21 (8): 1889–98. doi:10.1093/emboj/21.8.1889. ISSN 0261-4189. PMC 125975. PMID 11953308. Cite uses deprecated parameters (help)
↑ Vincenz, C; Dixit V M (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. (UNITED STATES) 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. ISSN 0021-9258. PMID 8702721. Cite uses deprecated parameters (help)
↑ Toyo-oka, Kazuhito; Shionoya Aki, Gambello Michael J, Cardoso Carlos, Leventer Richard, Ward Heather L, Ayala Ramses, Tsai Li-Huei, Dobyns William, Ledbetter David, Hirotsune Shinji, Wynshaw-Boris Anthony (July 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. (United States) 34 (3): 274–85. doi:10.1038/ng1169. ISSN 1061-4036. PMID 12796778. Cite uses deprecated parameters (help)
↑ Miska, E A; Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001). "Differential localization of HDAC4 orchestrates muscle differentiation". Nucleic Acids Res. (England) 29 (16): 3439–47. doi:10.1093/nar/29.16.3439. PMC 55849. PMID 11504882. Cite uses deprecated parameters (help)
↑ Grozinger, C M; Schreiber S L (July 2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7835–40. doi:10.1073/pnas.140199597. ISSN 0027-8424. PMC 16631. PMID 10869435. Cite uses deprecated parameters (help)
↑ Fanger, G R; Widmann C, Porter A C, Sather S, Johnson G L, Vaillancourt R R (February 1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. (UNITED STATES) 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. ISSN 0021-9258. PMID 9452471. Cite uses deprecated parameters (help)

Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
Jones DH, Ley S, Aitken A (1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins". FEBS Lett. 368 (1): 55–8. doi:10.1016/0014-5793(95)00598-4. PMID 7615088.
Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. doi:10.1073/pnas.92.17.7892. PMC 41252. PMID 7644510.
Jin DY, Lyu MS, Kozak CA, Jeang KT (1996). "Function of 14-3-3 proteins". Nature 382 (6589): 308. doi:10.1038/382308a0. PMID 8684458.
Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
Chong SS, Tanigami A, Roschke AV, Ledbetter DH (1997). "14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region". Genome Res. 6 (8): 735–41. doi:10.1101/gr.6.8.735. PMID 8858348.
Craparo A, Freund R, Gustafson TA (1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. PMID 9111084.
Han L, Wong D, Dhaka A (1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 4954–9. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
Ogihara T, Isobe T, Ichimura T (1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J. Biol. Chem. 272 (40): 25267–74. doi:10.1074/jbc.272.40.25267. PMID 9312143.
Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.
Nagata K, Puls A, Futter C (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Fanger GR, Widmann C, Porter AC (1998). "14-3-3 proteins interact with specific MEK kinases". J. Biol. Chem. 273 (6): 3476–83. doi:10.1074/jbc.273.6.3476. PMID 9452471.
Ku NO, Liao J, Omary MB (1998). "Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins". EMBO J. 17 (7): 1892–906. doi:10.1093/emboj/17.7.1892. PMC 1170536. PMID 9524113.
Luk SC, Ngai SM, Tsui SK (1999). "In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation". J. Cell. Biochem. 73 (1): 31–5. doi:10.1002/(SICI)1097-4644(19990401)73:1<31::AID-JCB4>3.0.CO;2-X. PMID 10088721.
Ostrerova N, Petrucelli L, Farrer M (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci. 19 (14): 5782–91. PMID 10407019.
Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID 10441394.
Dorner C, Ullrich A, Häring HU, Lammers R (1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
Aoki H, Hayashi J, Moriyama M (2000). "Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1". J. Virol. 74 (4): 1736–41. doi:10.1128/JVI.74.4.1736-1741.2000. PMC 111649. PMID 10644344.

PDB gallery

2br9: 14-3-3 PROTEIN EPSILON (HUMAN) COMPLEXED TO PEPTIDE

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT

see JAK-STAT signaling pathway

Growth factor receptor-bound protein

Other

14-3-3 YWHAE YWHAZ Caveolin Cortactin Death-inducing signaling complex Paxillin MYD88 SMAD TRAF TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6) BIN1 SH3BP2 LDB3

CHM CHML

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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YWHAE

Interactions

See also

References

Further reading