YTHDC1

From Wikipedia, the free encyclopedia

YTH domain containing 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2YUD

Identifiers

YTHDC1; YT521; YT521-B

External IDs

HomoloGene: 15796 GeneCards: YTHDC1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus
Biological process	• mRNA processing • RNA splicing
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000083896

ENSMUSG00000035851

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
69.18 – 69.22 Mb

Chr 5:
86.8 – 86.84 Mb

PubMed search

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.^[1]^[2]^[3]

Interactions

YTHDC1 has been shown to interact with Emerin,^[4] C-src tyrosine kinase,^[5] KHDRBS1^[2] and Abl gene.^[5]

References

↑ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
↑ 2.0 2.1 Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell 10 (11): 3909–26. PMC 25688. PMID 10564280.
↑ "Entrez Gene: YTHDC1 YTH domain containing 1".
↑ Wilkinson, Fiona L; Holaska James M, Zhang Zhayi, Sharma Aarti, Manilal Sushila, Holt Ian, Stamm Stefan, Wilson Katherine L, Morris Glenn E (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. (Germany) 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. ISSN 0014-2956. PMID 12755701. Cite uses deprecated parameters (help)
↑ 5.0 5.1 Rafalska, Ilona; Zhang Zhaiyi, Benderska Natalya, Wolff Horst, Hartmann Annette M, Brack-Werner Ruth, Stamm Stefan (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. (England) 13 (15): 1535–49. doi:10.1093/hmg/ddh167. ISSN 0964-6906. PMID 15175272. Cite uses deprecated parameters (help)

Further reading

Imai Y, Matsuo N, Ogawa S, et al. (1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation.". Brain Res. Mol. Brain Res. 53 (1-2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
Nayler O, Hartmann AM, Stamm S (2000). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment.". J. Cell Biol. 150 (5): 949–62. doi:10.1083/jcb.150.5.949. PMC 2175241. PMID 10973987.
Stoss O, Olbrich M, Hartmann AM, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.". J. Biol. Chem. 276 (12): 8665–73. doi:10.1074/jbc.M006851200. PMID 11118435.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins.". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wilkinson FL, Holaska JM, Zhang Z, et al. (2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B.". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rafalska I, Zhang Z, Benderska N, et al. (2005). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Stoss O, Novoyatleva T, Gencheva M, et al. (2005). "p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1.". Mol. Cell. Neurosci. 27 (1): 8–21. doi:10.1016/j.mcn.2004.04.011. PMID 15345239.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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