YKT6
From Wikipedia, the free encyclopedia
| YKT6 v-SNARE homolog (S. cerevisiae) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | YKT6 | ||||||||||||
| External IDs | OMIM: 606209 MGI: 1927550 HomoloGene: 4778 GeneCards: YKT6 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10652 | 56418 | |||||||||||
| Ensembl | ENSG00000106636 | ENSMUSG00000002741 | |||||||||||
| UniProt | O15498 | Q9CQW1 | |||||||||||
| RefSeq (mRNA) | NM_006555 | NM_019661 | |||||||||||
| RefSeq (protein) | NP_006546 | NP_062635 | |||||||||||
| Location (UCSC) | Chr 7: 44.24 – 44.25 Mb | Chr 11: 5.96 – 5.97 Mb | |||||||||||
| PubMed search | |||||||||||||
Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.[1][2][3]
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.[3]
Interactions
YKT6 has been shown to interact with BET1L.[4][5]
References
- ↑ Veit M (November 2004). "The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues". Biochem J 384 (Pt 2): 233–7. doi:10.1042/BJ20041474. PMC 1134105. PMID 15479160.
- ↑ Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F (November 2004). "Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators". Trends Biochem Sci 29 (12): 682–8. doi:10.1016/j.tibs.2004.10.002. PMID 15544955.
- ↑ 3.0 3.1 "Entrez Gene: YKT6 YKT6 v-SNARE homolog (S. cerevisiae)".
- ↑ Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603.
- ↑ Xu, Yue; Martin Sally, James David E, Hong Wanjin (October 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell (United States) 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. ISSN 1059-1524. PMC 129961. PMID 12388752.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- McNew JA, Sogaard M, Lampen NM, et al. (1997). "Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport". J. Biol. Chem. 272 (28): 17776–83. doi:10.1074/jbc.272.28.17776. PMID 9211930.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Tochio H, Tsui MM, Banfield DK, Zhang M (2001). "An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p". Science 293 (5530): 698–702. doi:10.1126/science.1062950. PMID 11474112.
- Honer WG, Falkai P, Bayer TA, et al. (2002). "Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness". Cereb. Cortex 12 (4): 349–56. doi:10.1093/cercor/12.4.349. PMID 11884350.
- Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
- Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Puri N, Kruhlak MJ, Whiteheart SW, Roche PA (2004). "Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly". J. Immunol. 171 (10): 5345–52. PMID 14607937.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fukasawa M, Varlamov O, Eng WS, et al. (2004). "Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation". Proc. Natl. Acad. Sci. U.S.A. 101 (14): 4815–20. doi:10.1073/pnas.0401183101. PMC 387331. PMID 15044687.
- Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
- Ooe A, Kato K, Noguchi S (2007). "Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers". Breast Cancer Res. Treat. 101 (3): 305–15. doi:10.1007/s10549-006-9293-x. PMID 16821082.
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