Y-27632
From Wikipedia, the free encyclopedia
Y-27632 | |
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IUPAC name (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide | |
Identifiers | |
CAS number | 146986-50-7 |
PubChem | 448042 |
ChemSpider | 20016532 |
DrugBank | DB08756 |
ChEBI | CHEBI:75393 |
Jmol-3D images | {{#if:O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2|Image 1 |
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Properties | |
Molecular formula | C14H21N3O |
Molar mass | 247.34 g mol−1 |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways.[1] Y-27632 selectively inhibits p160ROCK.[2]
References
- ↑ Uehata, Masayoshi (1999). "Y-27632. Selective probe of ROCK/Rho-kinase". Jikken Igaku 17 (7): 850–855.
- ↑ Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; Morishita, T; Tamakawa, H; Yamagami, K et al. (1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature 389 (6654): 990–4. doi:10.1038/40187. PMID 9353125.
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