WNT3A

Wingless-type MMTV integration site family, member 3A
Identifiers
Symbols	WNT3A; MGC119418; MGC119419; MGC119420
External IDs	OMIM: 606359 MGI: 98956 HomoloGene: 22528 ChEMBL: 1255137 GeneCards: WNT3A Gene
Gene Ontology Molecular function • transcription coactivator activity • frizzled-2 binding • extracellular matrix structural constituent • protein binding • protein domain specific binding • receptor agonist activity Cellular component • extracellular region • proteinaceous extracellular matrix • extracellular space • early endosome • late endosome • plasma membrane • cell surface • membrane raft Biological process • osteoblast differentiation • in utero embryonic development • somitogenesis • positive regulation of protein phosphorylation • heart looping • positive regulation of receptor internalization • negative regulation of heart induction by canonical Wnt receptor signaling pathway • Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • determination of left/right symmetry • axonogenesis • axon guidance • positive regulation of cell proliferation • anatomical structure morphogenesis • axis specification • embryonic pattern specification • signalosome assembly • negative regulation of neuron projection development • spinal cord association neuron differentiation • hippocampus development • cell proliferation in forebrain • Wnt receptor signaling pathway involved in forebrain neuroblast division • dorsal/ventral neural tube patterning • neuron differentiation • extracellular matrix organization • mammary gland development • positive regulation of B cell proliferation • notochord development • midbrain-hindbrain boundary development • positive regulation of protein binding • positive regulation of peptidyl-serine phosphorylation • cellular protein localization • positive regulation of catenin import into nucleus • skeletal muscle cell differentiation • post-anal tail morphogenesis • inner ear morphogenesis • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of fat cell differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mesodermal cell fate specification • paraxial mesodermal cell fate commitment • positive regulation of collateral sprouting in absence of injury • negative regulation of axon extension involved in axon guidance • negative regulation of neurogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • palate development • convergent extension • canonical Wnt receptor signaling pathway • positive regulation of protein tyrosine kinase activity • positive regulation of dermatome development • canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment • regulation of microtubule cytoskeleton organization • platelet aggregation • cellular response to retinoic acid • hematopoietic stem cell proliferation • axis elongation involved in somitogenesis • positive regulation of canonical Wnt receptor signaling pathway • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation • positive regulation of cardiac muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	89780	22416
Ensembl	ENSG00000154342	ENSMUSG00000009900
UniProt	P56704	P27467
RefSeq (mRNA)	NM_033131	NM_009522
RefSeq (protein)	NP_149122	NP_033548
Location (UCSC)	Chr 1: 228.19 – 228.25 Mb	Chr 11: 59.25 – 59.29 Mb
PubMed search
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Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.^[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.^[2]

References

Further reading