WNK3

From Wikipedia, the free encyclopedia

WNK lysine deficient protein kinase 3

Identifiers

Symbols

WNK3; PRKWNK3

External IDs

OMIM: 300358 MGI: 2652875 HomoloGene: 32493 ChEMBL: 6055 GeneCards: WNK3 Gene

EC number

2.7.11.1

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding
Cellular component	• cytoplasm • adherens junction • tight junction
Biological process	• protein phosphorylation • intracellular protein kinase cascade • positive regulation of sodium ion transport • positive regulation of peptidyl-threonine phosphorylation • positive regulation of ion transmembrane transporter activity • negative regulation of apoptotic process • protein autophosphorylation • positive regulation of calcium ion transport • positive regulation of establishment of protein localization to plasma membrane • regulation of ion homeostasis • positive regulation of sodium ion transmembrane transporter activity • positive regulation of rubidium ion transport • positive regulation of rubidium ion transmembrane transporter activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr HG1433_PATCH:
53.94 – 54.1 Mb

Chr X:
147.63 – 147.75 Mb

PubMed search

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.^[1]

Function

WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca²⁺ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.^[1]

References

↑ 1.0 1.1 "Entrez Gene: WNK lysine deficient protein kinase 3".

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Yang CL, Zhu X, Ellison DH (2007). "The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex". J. Clin. Invest. 117 (11): 3403–11. doi:10.1172/JCI32033. PMID 17975670.
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Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Qiao Y, Liu X, Harvard C, et al. (2008). "Autism-associated familial microdeletion of Xp11.22". Clin. Genet. 74 (2): 134–44. doi:10.1111/j.1399-0004.2008.01028.x. PMID 18498374.
Wilson FH, Disse-Nicodème S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.
Heise CJ, Xu BE, Deaton SL, et al. (2010). "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members". J. Biol. Chem. 285 (33): 25161–7. doi:10.1074/jbc.M110.103432. PMID 20525693.
Holden S, Cox J, Raymond FL (2004). "Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)". Gene 335: 109–19. doi:10.1016/j.gene.2004.03.009. PMID 15194194.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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WNK3

Function

References

Further reading