VTI1A

From Wikipedia, the free encyclopedia

Vesicle transport through interaction with t-SNAREs 1A

PDB rendering based on 2nps.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1vcs, 2nps

Identifiers

VTI1A; MVti1; VTI1RP2; Vti1-rp2

External IDs

OMIM: 614316 MGI: 1855699 HomoloGene: 39963 GeneCards: VTI1A Gene

Gene Ontology
Molecular function	• SNAP receptor activity
Cellular component	• Golgi membrane • Golgi apparatus • integral to membrane • cytoplasmic membrane-bounded vesicle • SNARE complex
Biological process	• intracellular protein transport • retrograde transport, endosome to Golgi
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000151532

ENSMUSG00000024983

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
114.21 – 114.58 Mb

Chr 19:
55.32 – 55.63 Mb

PubMed search

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.^[1]^[2]

The protein encoded by the VTI1A gene is a target-SNARE (t-SNARE) protein which is located in the membranes of target vesicle compartments.

References

↑ "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
↑ Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.

Further reading

Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.

PDB gallery

2nps: Crystal Structure of the Early Endosomal SNARE Complex

1vcs: Solution Structure of RSGI RUH-009, an N-Terminal Domain of Vti1a [Mus musculus]

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