VPS33B
From Wikipedia, the free encyclopedia
| Vacuolar protein sorting 33 homolog B (yeast) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | VPS33B; FLJ14848 | ||||||||||||
| External IDs | OMIM: 608552 MGI: 2446237 HomoloGene: 10261 GeneCards: VPS33B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26276 | 233405 | |||||||||||
| Ensembl | ENSG00000184056 | ENSMUSG00000030534 | |||||||||||
| UniProt | Q9H267 | P59016 | |||||||||||
| RefSeq (mRNA) | NM_018668 | NM_178070 | |||||||||||
| RefSeq (protein) | NP_061138 | NP_835171 | |||||||||||
| Location (UCSC) | Chr 15: 91.54 – 91.57 Mb | Chr 7: 80.27 – 80.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.[1][2]
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[2]
References
- ↑ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene 183 (1-2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
- ↑ 2.0 2.1 "Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)".
Further reading
- Carim L, Sumoy L, Andreu N, et al. (2000). "Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b.". Cytogenet. Cell Genet. 89 (1-2): 92–5. doi:10.1159/000015571. PMID 10894945.
- Huizing M, Didier A, Walenta J, et al. (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.". Gene 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gissen P, Johnson CA, Morgan NV, et al. (2004). "Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.". Nat. Genet. 36 (4): 400–4. doi:10.1038/ng1325. PMID 15052268.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gissen P, Johnson CA, Gentle D, et al. (2005). "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights.". Hum. Mol. Genet. 14 (10): 1261–70. doi:10.1093/hmg/ddi137. PMID 15790593.
- Lo B, Li L, Gissen P, et al. (2006). "Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis.". Blood 106 (13): 4159–66. doi:10.1182/blood-2005-04-1356. PMID 16123220.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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