VIPR1

From Wikipedia, the free encyclopedia

Vasoactive intestinal peptide receptor 1

Rendering of VIPR1 from PDB 1OF2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1OF2, 1OGT, 3B3I

Identifiers

Symbols

VIPR1; HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG; VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R

External IDs

OMIM: 192321 MGI: 109272 HomoloGene: 3399 IUPHAR: VPAC₁ ChEMBL: 5144 GeneCards: VIPR1 Gene

Gene Ontology
Molecular function	• vasoactive intestinal polypeptide receptor activity
Cellular component	• nucleus • nucleolus • cytoplasm • plasma membrane • integral to plasma membrane
Biological process	• muscle contraction • immune response • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • synaptic transmission • digestion • positive regulation of cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
42.53 – 42.58 Mb

Chr 9:
121.64 – 121.67 Mb

PubMed search

Vasoactive intestinal polypeptide receptor 1 also known as VPAC₁, is a protein, that in humans is encoded by the VIPR1 gene.^[1] VPAC₁ is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis.^[2]^[3]^[4]

Function

VPAC₁ is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.^[1]

VIP acts in an autocrine fashion via VPAC₁1 to inhibit megakaryocyte proliferation and induce proplatelet formation. ^[5]^[6]

Clinical Significance

Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1.^[7]

VIP and PACAP levels were decreased in anterior vaginal wall of stress urinary incontinence and pelvic organ prolapse patients, they may participate in the pathophysiology of these diseases.^[8]

References

↑ 1.0 1.1 "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".
↑ Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. (1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.". Neuron 8 (4): 811–819. doi:10.1016/0896-6273(92)90101-I. PMID 1314625.
↑ Usdin TB, Bonner TI, Mezey E. (1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions.". Endocrinology 135 (6): 2662–2680. doi:10.1210/en.135.6.2662. PMID 7988457.
↑ Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ. (1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proc Natl Acad Sci USA 92 (7): 2939–2943. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
↑ Nam, C.; Case, A. J.; Hostager, B. S.; O’Dorisio, M. S. (2008). "The Role of Vasoactive Intestinal Peptide (VIP) in Megakaryocyte Proliferation". Journal of Molecular Neuroscience 37 (2): 160–167. doi:10.1007/s12031-008-9119-x. PMID 18663606.
↑ Freson, K.; Peeters, K.; De Vos, R.; Wittevrongel, C.; Thys, C.; Hoylaerts, M. F.; Vermylen, J.; Van Geet, C. (2007). "PACAP and its receptor VPAC1 regulate megakaryocyte maturation: Therapeutic implications". Blood 111 (4): 1885–1893. doi:10.1182/blood-2007-06-098558. PMID 18000164.
↑ Paladini, F.; Cocco, E.; Cascino, I.; Belfiore, F.; Badiali, D.; Piretta, L.; Alghisi, F.; Anzini, F. et al. (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterol Motil 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID 19309439. |displayauthors= suggested (help)
↑ Hong, X.; Huang, L.; Song, Y. (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". Int Urogynecol J Pelvic Floor Dysfunct 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID 18351280.

"Quaternary structure of rabbit skeletal muscle glycogen synthetase" [Quaternary structure of rabbit skeletal muscle glycogen synthetase]. Doklady Akademii Nauk SSSR 222 (4): 997–1000. 1975. PMID 807467.
Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2939–43. doi:10.1073/pnas.92.7.2939. PMC 42334. PMID 7708752.
Couvineau A, Gaudin P, Maoret JJ, et al. (1995). "Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP". Biochem. Biophys. Res. Commun. 206 (1): 246–52. doi:10.1006/bbrc.1995.1034. PMID 7818527.
Gagnon AW, Aiyar N, Elshourbagy NA (1994). "Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor". Cell. Signal. 6 (3): 321–33. doi:10.1016/0898-6568(94)90037-X. PMID 7917790.
Sreedharan SP, Patel DR, Xia M, et al. (1994). "Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways". Biochem. Biophys. Res. Commun. 203 (1): 141–8. doi:10.1006/bbrc.1994.2160. PMID 8074647.
Couvineau A, Rouyer-Fessard C, Darmoul D, et al. (1994). "Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains". Biochem. Biophys. Res. Commun. 200 (2): 769–76. doi:10.1006/bbrc.1994.1517. PMID 8179610.
Moody TW, Zia F, Draoui M, et al. (1993). "A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4345–9. doi:10.1073/pnas.90.10.4345. PMC 46507. PMID 8389448.
Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
Couvineau A, Fabre C, Gaudin P, et al. (1996). "Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane". Biochemistry 35 (6): 1745–52. doi:10.1021/bi952022h. PMID 8639654.
Pozo D, Guerrero JM, Segura JJ, Calvo JR (1997). "Thymosin alpha 1 interacts with the VIP receptor-effector system in rat and mouse immunocompetent cells". Immunopharmacology 34 (2–3): 113–23. doi:10.1016/0162-3109(96)00131-2. PMID 8886855.
Couvineau A, Maoret JJ, Rouyer-Fessard C, et al. (1999). "Cloning and functional characterization of the human VIP1/PACAP receptor promoter". Ann. N. Y. Acad. Sci. 865: 59–63. doi:10.1111/j.1749-6632.1998.tb11163.x. PMID 9927997.
Knudsen SM, Tams JW, Wulff BS, Fahrenkrug J (1999). "Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production". Ann. N. Y. Acad. Sci. 865: 259–65. doi:10.1111/j.1749-6632.1998.tb11186.x. PMID 9928020.
Marie J, Wakkach A, Coudray A, et al. (1999). "Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients". J. Immunol. 162 (4): 2103–12. PMID 9973484.
Mimuro H, Suzuki T, Suetsugu S, et al. (2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.
Nicole P, Maoret JJ, Couvineau A, et al. (2000). "Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding". Biochem. Biophys. Res. Commun. 276 (2): 654–9. doi:10.1006/bbrc.2000.3375. PMID 11027527.
Bajo AM, Juarranz MG, Valenzuela P, et al. (2001). "Expression of vasoactive intestinal peptide (VIP) receptors in human uterus". Peptides 21 (9): 1383–8. doi:10.1016/S0196-9781(00)00282-5. PMID 11072126.
Lara-Marquez M, O'Dorisio M, O'Dorisio T, et al. (2001). "Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells". J. Immunol. 166 (4): 2522–30. PMID 11160313.
Martin Shreeve S (2002). "Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling". Biochem. Biophys. Res. Commun. 290 (4): 1300–7. doi:10.1006/bbrc.2002.6342. PMID 11812005.
Dorsam G, Goetzl EJ (2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros". J. Biol. Chem. 277 (16): 13488–93. doi:10.1074/jbc.M107922200. PMID 11812772.
Branch DR, Valenta LJ, Yousefi S, et al. (2002). "VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection". AIDS 16 (3): 309–19. doi:10.1097/00002030-200202150-00001. PMID 11834941.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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VIPR1

Function

Clinical Significance

See also

References

Further reading