Uroporphyrinogen-III C-methyltransferase
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| Uroporphyrinogen-III C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.107 | ||||||||
| CAS number | 125752-76-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107, uroporphyrinogen methyltransferase, uroporphyrinogen-III methyltransferase, adenosylmethionine-uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase, uroporphyrinogen-III methylase, SirA, CysG, uroporphyrin-III C-methyltransferase, S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase) is an enzyme with system name S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + uroporphyrinogen III
2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction) - (1a) S-adenosyl-L-methionine + uroporphyrinogen III S-adenosyl-L-homocysteine + precorrin-1
- (1b) S-adenosyl-L-methionine + precorrin-1 S-adenosyl-L-homocysteine + precorrin-2
Uroporphyrinogen-III C-methyltransferase catalyses two methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2.
References
- ↑ Warren, M.J., Gonzalez, M.D., Williams, H.J., Stolowich, N.J. and Scott, A.I. (1990). "Uroporphyrinogen-III methylase catalyzes the enzymatic-synthesis of sirohydrochlorin-II and sirohydrochlorin-IV by a clockwise mechanism". J. Am. Chem. Soc. 112: 5343–5345.
- ↑ Warren, M.J., Roessner, C.A., Santander, P.J. and Scott, A.I. (1990). "The Escherichia coli cysG gene encodes S-adenosylmethionine-dependent uroporphyrinogen III methylase". Biochem. J. 265 (3): 725–729. PMID 2407234.
- ↑ Schubert, H.L., Raux, E., Brindley, A.A., Leech, H.K., Wilson, K.S., Hill, C.P. and Warren, M.J. (2002). "The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase". EMBO J. 21: 2068–2075. doi:10.1093/emboj/21.9.2068. PMC 125995. PMID 11980703.
External links
- Uroporphyrinogen-III C-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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