Unoprostone

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Unoprostone

Systematic (IUPAC) name
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl) cyclopentyl]hept-5-enoic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Legal status	?
Routes	Topical (eye drops)
Identifiers
CAS number	120373-36-6^Y 120373-24-2
ATC code	S01EE02
PubChem	CID 5311236
ChemSpider	4470755^N
UNII	6X4F561V3W^N
KEGG	D08661^Y
ChEMBL	CHEMBL1201407^N
Chemical data
Formula	C₂₂H₃₈O₅
Mol. mass	382.534 g/mol
SMILES O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCCCCCC
InChI InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1^N Key:TVHAZVBUYQMHBC-SNHXEXRGSA-N^N
N (what is this?) (verify)

Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, is marketed under the trade name Rescula (eyedrops, 0.15%) for the management of open-angle glaucoma and ocular hypertension.

References

Ophthalmologicals: antiglaucoma preparations and miotics (S01E)

muscarinic	Aceclidine Pilocarpine

muscarinic/nicotinic	Acetylcholine Carbachol

Acetylcholinesterase inhibitors	Demecarium Ecothiopate Stigmine (Fluostigmine Neostigmine Physostigmine) Paraoxon

Other agents

anat (g/a/p)/phys/devp/prot

noco/cong/tumr, epon

proc, drug (S1A/1E/1F/1L)

Precursor

Precursor

Active

D/J	D₂

E/F	E₂ (Dinoprostone): Enprostil Sulprostone E₁ (Alprostadil): Misoprostol Gemeprost F_2α (Dinoprost): Bimatoprost Carboprost Latanoprost Tafluprost Travoprost Unoprostone

I	I₂ (Prostacyclin/Epoprostenol): Beraprost Iloprost Treprostinil

Precursor	Arachidonic acid 5-hydroperoxide

Initial	A₄ B₄

SRS-A	C₄ D₄ E₄

By function

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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