USP9X

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Ubiquitin specific peptidase 9, X-linked
Identifiers
SymbolsUSP9X; DFFRX; FAF; FAM
External IDsOMIM: 300072 MGI: 894681 HomoloGene: 3418 GeneCards: USP9X Gene
EC number3.4.19.12
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez823922284
EnsemblENSG00000124486ENSMUSG00000031010
UniProtQ93008P70398
RefSeq (mRNA)NM_001039590NM_009481
RefSeq (protein)NP_001034679NP_033507
Location (UCSC)Chr X:
40.94 – 41.09 Mb
Chr X:
13.07 – 13.17 Mb
PubMed search

Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the USP9X gene.[1][2]

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation.

Interactions

USP9X has been shown to interact with Beta-catenin,[3] MARK4,[4] NUAK1[4] and MLLT4.[3][5]

References

  1. Jones MH, Furlong RA, Burkin H, Chalmers IJ, Brown GM, Khwaja O, Affara NA (Mar 1997). "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2". Hum Mol Genet 5 (11): 1695–701. doi:10.1093/hmg/5.11.1695. PMID 8922996. 
  2. "Entrez Gene: USP9X ubiquitin specific peptidase 9, X-linked". 
  3. 3.0 3.1 Taya, S; Yamamoto T, Kanai-Azuma M, Wood S A, Kaibuchi K (Dec 1999). "The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin". Genes Cells (ENGLAND) 4 (12): 757–67. doi:10.1046/j.1365-2443.1999.00297.x. ISSN 1356-9597. PMID 10620020. 
  4. 4.0 4.1 Al-Hakim, Abdallah K; Zagorska Anna, Chapman Louise, Deak Maria, Peggie Mark, Alessi Dario R (Apr 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". Biochem. J. (England) 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. 
  5. Taya, S; Yamamoto T, Kano K, Kawano Y, Iwamatsu A, Tsuchiya T, Tanaka K, Kanai-Azuma M, Wood S A, Mattick J S, Kaibuchi K (Aug 1998). "The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme". J. Cell Biol. (UNITED STATES) 142 (4): 1053–62. doi:10.1083/jcb.142.4.1053. ISSN 0021-9525. PMC 2132865. PMID 9722616. 

Further reading


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