USP5
From Wikipedia, the free encyclopedia
| Ubiquitin specific peptidase 5 (isopeptidase T) | |||||||||||||
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 PDB rendering based on 2dag. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | USP5; ISOT | ||||||||||||
| External IDs | OMIM: 601447 MGI: 1347343 HomoloGene: 55758 ChEMBL: 6158 GeneCards: USP5 Gene | ||||||||||||
| EC number | 3.4.19.12 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8078 | 22225 | |||||||||||
| Ensembl | ENSG00000111667 | ENSMUSG00000038429 | |||||||||||
| UniProt | P45974 | P56399 | |||||||||||
| RefSeq (mRNA) | NM_001098536 | NM_013700 | |||||||||||
| RefSeq (protein) | NP_001092006 | NP_038728 | |||||||||||
| Location (UCSC) | Chr 12: 6.96 – 6.98 Mb | Chr 6: 124.82 – 124.83 Mb | |||||||||||
| PubMed search | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 5 is an enzyme that in humans is encoded by the USP5 gene.[1][2][3]
Interactions
USP5 has been shown to interact with TADA3L.[4]
References
- ↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
- ↑ Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
- ↑ "Entrez Gene: USP5 ubiquitin specific peptidase 5 (isopeptidase T)".
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
- Falquet L, Paquet N, Frutiger S, et al. (1996). "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2).". FEBS Lett. 376 (3): 233–7. doi:10.1016/0014-5793(95)01287-7. PMID 7498549.
- Wilkinson KD, Tashayev VL, O'Connor LB, et al. (1995). "Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.". Biochemistry 34 (44): 14535–46. doi:10.1021/bi00044a032. PMID 7578059.
- Falquet L, Paquet N, Frutiger S, et al. (1995). "A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro.". FEBS Lett. 359 (1): 73–7. doi:10.1016/0014-5793(94)01451-6. PMID 7851534.
- Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
- Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
- Engidawork E, Juranville JF, Fountoulakis M, et al. (2002). "Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.". J. Neural Transm. Suppl. (61): 117–30. PMID 11771738.
- Gabriel JM, Lacombe T, Carobbio S, et al. (2002). "Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T.". Biochemistry 41 (46): 13755–66. doi:10.1021/bi026096m. PMID 12427038.
- Lacombe T, Gabriel JM (2002). "Further characterization of the putative human isopeptidase T catalytic site.". FEBS Lett. 531 (3): 469–74. doi:10.1016/S0014-5793(02)03586-X. PMID 12435595.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Reyes-Turcu FE, Horton JR, Mullally JE, et al. (2006). "The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.". Cell 124 (6): 1197–208. doi:10.1016/j.cell.2006.02.038. PMID 16564012.
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