USP26
From Wikipedia, the free encyclopedia
| ubiquitin specific peptidase 26 | |
|---|---|
| Identifiers | |
| Symbol | USP26 |
| Entrez | 83844 |
| HUGO | 13485 |
| OMIM | 300309 |
| RefSeq | NM_031907 |
| UniProt | Q9BXU7 |
| Other data | |
| Locus | Chr. X q26.2 |
USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.[1]
Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,[1][2] specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).[3]
See also
References
- ↑ 1.0 1.1 Stouffs, Katrien; Willy Lissens, Herman Tournaye, André Van Steirteghem and Inge Liebaers (2005). "Possible role of USP26 in patients with severely impaired spermatogenesis". European Journal of Human Genetics 13: 336–340. doi:10.1038/sj.ejhg.5201335.
- ↑ Zhang J, Qiu SD, Li SB et al. (2007). "Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility". Asian J. Androl. 9 (6): 809–14. doi:10.1111/j.1745-7262.2007.00305.x. PMID 17968467.
- ↑ Ravel, C.; B. El Houate, S. Chantot, D. Lourenço, A. Dumaine, H. Rouba, A. Bandyopadahyay, U. Radhakrishna, B. Das, S. Sengupta, J. Mandelbaum, J.P. Siffroi and K. McElreavey (October 2006). "Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26". Mol. Hum. Reprod. 12 (10): 643–646. doi:10.1093/molehr/gal063.
External links
- USP26 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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