USP18

From Wikipedia, the free encyclopedia

Ubiquitin specific peptidase 18

Identifiers

USP18; ISG43; UBP43

External IDs

OMIM: 607057 MGI: 1344364 HomoloGene: 8047 GeneCards: USP18 Gene

Gene Ontology
Molecular function	• ubiquitin thiolesterase activity • ubiquitin-specific protease activity
Cellular component	• nucleus • cytosol
Biological process	• ubiquitin-dependent protein catabolic process • cytokine-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000184979

ENSMUSG00000030107

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
18.63 – 18.66 Mb

Chr 6:
121.25 – 121.27 Mb

PubMed search

Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is a gene.^[1]

USP18, a member of the deubiquitinating protease family of enzymes, is thought to remove ISG15 adducts from a broad range of protein substrates.[supplied by OMIM]^[1]

References

↑ 1.0 1.1 "Entrez Gene: USP18 ubiquitin specific peptidase 18".

Further reading

Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach.". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
Li XL, Blackford JA, Judge CS, et al. (2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response.". J. Biol. Chem. 275 (12): 8880–8. doi:10.1074/jbc.275.12.8880. PMID 10722734.
Schwer H, Liu LQ, Zhou L, et al. (2000). "Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).". Genomics 65 (1): 44–52. doi:10.1006/geno.2000.6148. PMID 10777664.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kang D, Jiang H, Wu Q, et al. (2001). "Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.". Gene 267 (2): 233–42. doi:10.1016/S0378-1119(01)00384-5. PMID 11313150.
Malakhov MP, Malakhova OA, Kim KI, et al. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins.". J. Biol. Chem. 277 (12): 9976–81. doi:10.1074/jbc.M109078200. PMID 11788588.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tokarz S, Berset C, La Rue J, et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.". J. Biol. Chem. 279 (45): 46424–30. doi:10.1074/jbc.M403189200. PMID 15342634.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Yan M, Luo JK, Ritchie KJ, et al. (2007). "Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.". Blood 110 (1): 305–12. doi:10.1182/blood-2006-07-033209. PMC 1896118. PMID 17374743.

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