USP11
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| Ubiquitin specific peptidase 11 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | USP11; UHX1 | ||||||||||||
| External IDs | OMIM: 300050 MGI: 2384312 HomoloGene: 31252 GeneCards: USP11 Gene | ||||||||||||
| EC number | 3.4.19.12 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8237 | 236733 | |||||||||||
| Ensembl | ENSG00000102226 | ENSMUSG00000031066 | |||||||||||
| UniProt | P51784 | Q99K46 | |||||||||||
| RefSeq (mRNA) | NM_004651 | NM_145628 | |||||||||||
| RefSeq (protein) | NP_004642 | NP_663603 | |||||||||||
| Location (UCSC) | Chr X: 47.09 – 47.11 Mb | Chr X: 20.7 – 20.72 Mb | |||||||||||
| PubMed search | |||||||||||||
Ubiquitin carboxyl-terminal hydrolase 11 is an enzyme that in humans is encoded by the USP11 gene.[1][2]
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23[2]
Interactions
USP11 has been shown to interact with RANBP9.[3]
References
- ↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
- ↑ 2.0 2.1 "Entrez Gene: USP11 ubiquitin specific peptidase 11".
- ↑ Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct 2002). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. (England) 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. ISSN 0264-6021. PMC 1222860. PMID 12084015.
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
- Swanson DA, Freund CL, Ploder L et al. (1996). "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders". Hum. Mol. Genet. 5 (4): 533–8. doi:10.1093/hmg/5.4.533. PMID 8845848.
- Brandau O, Nyakatura G, Jedele KB et al. (1999). "UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2". Eur. J. Hum. Genet. 6 (5): 459–66. doi:10.1038/sj.ejhg.5200207. PMID 9801870.
- Stoddart KL, Jermak C, Nagaraja R et al. (1999). "Physical map covering a 2 Mb region in human xp11.3 distal to DX6849". Gene 227 (1): 111–6. doi:10.1016/S0378-1119(98)00564-2. PMID 9931462.
- Thiselton DL, McDowall J, Brandau O et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
- Ideguchi H, Ueda A, Tanaka M et al. (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Angelats C, Wang XW, Jermiin LS et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Schoenfeld AR, Apgar S, Dolios G et al. (2004). "BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage". Mol. Cell. Biol. 24 (17): 7444–55. doi:10.1128/MCB.24.17.7444-7455.2004. PMC 506974. PMID 15314155.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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