USP1

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Ubiquitin specific peptidase 1
Identifiers
SymbolsUSP1; UBP
External IDsOMIM: 603478 MGI: 2385198 HomoloGene: 2528 ChEMBL: 1795087 GeneCards: USP1 Gene
EC number3.4.19.12
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez7398230484
EnsemblENSG00000162607ENSMUSG00000028560
UniProtO94782Q8BJQ2
RefSeq (mRNA)NM_001017415NM_146144
RefSeq (protein)NP_001017415NP_666256
Location (UCSC)Chr 1:
62.9 – 62.92 Mb
Chr 4:
98.92 – 98.94 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.[1][2]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.[2]

References

  1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  2. 2.0 2.1 "Entrez Gene: USP1 ubiquitin specific peptidase 1". 

Further reading

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