USO1
From Wikipedia, the free encyclopedia
| USO1 vesicle transport factor | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | USO1; P115; TAP; VDP | ||||||||||||
| External IDs | OMIM: 603344 MGI: 1929095 HomoloGene: 2754 GeneCards: USO1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8615 | 56041 | |||||||||||
| Ensembl | ENSG00000138768 | ENSMUSG00000029407 | |||||||||||
| UniProt | O60763 | Q9Z1Z0 | |||||||||||
| RefSeq (mRNA) | NM_003715 | NM_019490 | |||||||||||
| RefSeq (protein) | NP_003706 | NP_062363 | |||||||||||
| Location (UCSC) | Chr 4: 76.65 – 76.74 Mb | Chr 5: 92.14 – 92.2 Mb | |||||||||||
| PubMed search | |||||||||||||
General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.[1][2][3][4][5][6]
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner.[6]
Interactions
USO1 has been shown to interact with GOSR1,[7] GOSR2,[7][8] SCFD1[7][8] and STX5.[7][8]
References
- ↑ Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y (March 1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane". J Biol Chem 273 (9): 5385–8. doi:10.1074/jbc.273.9.5385. PMID 9478999.
- ↑ Nakamura N, Lowe M, Levine TP, Rabouille C, Warren G (June 1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner". Cell 89 (3): 445–55. doi:10.1016/S0092-8674(00)80225-1. PMID 9150144.
- ↑ Whyte JR, Munro S (June 2002). "Vesicle tethering complexes in membrane traffic". J Cell Sci 115 (Pt 13): 2627–37. PMID 12077354.
- ↑ Short B, Haas A, Barr FA (June 2005). "Golgins and GTPases, giving identity and structure to the Golgi apparatus". Biochim Biophys Acta 1744 (3): 383–95. doi:10.1016/j.bbamcr.2005.02.001. PMID 15979508.
- ↑ Puthenveedu MA, Linstedt AD (February 2004). "Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis". Proc Natl Acad Sci U S A 101 (5): 1253–6. doi:10.1073/pnas.0306373101. PMC 337039. PMID 14736916.
- ↑ 6.0 6.1 "Entrez Gene: VDP vesicle docking protein p115".
- ↑ 7.0 7.1 7.2 7.3 Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603.
- ↑ 8.0 8.1 8.2 Allan, B B; Moyer B D, Balch W E (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science (UNITED STATES) 289 (5478): 444–8. doi:10.1126/science.289.5478.444. ISSN 0036-8075. PMID 10903204.
Further reading
- Waters MG, Clary DO, Rothman JE (1992). "A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack". J. Cell Biol. 118 (5): 1015–26. doi:10.1083/jcb.118.5.1015. PMC 2289595. PMID 1512287.
- Barr FA, Nakamura N, Warren G (1998). "Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae". EMBO J. 17 (12): 3258–68. doi:10.1093/emboj/17.12.3258. PMC 1170664. PMID 9628863.
- Nelson DS, Alvarez C, Gao YS, et al. (1998). "The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function". J. Cell Biol. 143 (2): 319–31. doi:10.1083/jcb.143.2.319. PMC 2132831. PMID 9786945.
- Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.
- Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments". J. Cell Biol. 150 (3): 475–88. doi:10.1083/jcb.150.3.475. PMC 2175190. PMID 10931861.
- Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic". J. Biol. Chem. 276 (4): 2693–700. doi:10.1074/jbc.M007957200. PMID 11035033.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Brunati AM, Marin O, Folda A, et al. (2001). "Possible implication of the Golgi apparatus casein kinase in the phosphorylation of vesicle docking protein p115 Ser-940: a study with peptide substrates". Biochem. Biophys. Res. Commun. 284 (3): 817–22. doi:10.1006/bbrc.2001.5049. PMID 11396975.
- Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
- Short B, Preisinger C, Schaletzky J, et al. (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177.
- Chiu R, Novikov L, Mukherjee S, Shields D (2003). "A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis". J. Cell Biol. 159 (4): 637–48. doi:10.1083/jcb.200208013. PMC 2173109. PMID 12438416.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Han SJ, Lee JH, Kim CG, Hong SH (2003). "Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport". Biochem. Biophys. Res. Commun. 300 (3): 649–55. doi:10.1016/S0006-291X(02)02884-X. PMID 12507498.
- García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890. PMID 12634853.
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