UQCRH

From Wikipedia, the free encyclopedia

Ubiquinol-cytochrome c reductase hinge protein

PDB rendering based on 1bcc.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1bcc, 1be3, 1bgy, 1l0l, 1l0n, 1ntk, 1ntm, 1ntz, 1nu1, 1pp9, 1ppj, 1qcr, 1sqb, 1sqp, 1sqq, 1sqv, 1sqx, 2a06, 2bcc, 2fyu, 3bcc

Identifiers

UQCRH; QCR6; UQCR8

External IDs

OMIM: 613844 MGI: 1913826 HomoloGene: 103848 GeneCards: UQCRH Gene

Gene Ontology
Molecular function	• ubiquinol-cytochrome-c reductase activity • protein complex binding
Cellular component	• mitochondrial inner membrane • mitochondrial respiratory chain • mitochondrial respiratory chain complex III
Biological process	• oxidative phosphorylation • mitochondrial electron transport, ubiquinol to cytochrome c • aerobic respiration • respiratory electron transport chain • small molecule metabolic process • protein heterooligomerization • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000173660

ENSMUSG00000063882

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
46.77 – 46.78 Mb

Chr 4:
116.07 – 116.08 Mb

PubMed search

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^[1]^[2]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

↑ Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.
↑ "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein".

Further reading

Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer.". Cancer Res. 53 (11): 2460–5. PMID 7684318.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene 22 (29): 4586–93. doi:10.1038/sj.onc.1206472. PMID 12881716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1bcc: CYTOCHROME BC1 COMPLEX FROM CHICKEN

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

1sqb: Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin

1sqp: Crystal Structure Analysis of Bovine Bc1 with Myxothiazol

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2bcc: STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

3bcc: STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

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