UQCRC2
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| Ubiquinol-cytochrome c reductase core protein II | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | UQCRC2; MC3DN5; QCR2; UQCR2 | ||||||||||||
| External IDs | OMIM: 191329 MGI: 1914253 HomoloGene: 37764 GeneCards: UQCRC2 Gene | ||||||||||||
| EC number | 1.10.2.2 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7385 | 67003 | |||||||||||
| Ensembl | ENSG00000140740 | ENSMUSG00000030884 | |||||||||||
| UniProt | P22695 | Q9DB77 | |||||||||||
| RefSeq (mRNA) | NM_003366 | NM_025899 | |||||||||||
| RefSeq (protein) | NP_003357 | NP_080175 | |||||||||||
| Location (UCSC) | Chr 16: 21.96 – 21.99 Mb | Chr 7: 120.64 – 120.66 Mb | |||||||||||
| PubMed search | |||||||||||||
Cytochrome b-c1 complex subunit 2, mitochondrial is a protein that in humans is encoded by the UQCRC2 gene.[1][2][3]
Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".
References
- ↑ Duncan AM, Ozawa T, Suzuki H, Rozen R (Feb 1994). "Assignment of the gene for the core protein II (UQCRC2) subunit of the mitochondrial cytochrome bc1 complex to human chromosome 16p12". Genomics 18 (2): 455–6. doi:10.1006/geno.1993.1500. PMID 8288258.
- ↑ Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T (Sep 1989). "Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart". J Biol Chem 264 (23): 13483–8. PMID 2547763.
- ↑ "Entrez Gene: UQCRC2 ubiquinol-cytochrome c reductase core protein II".
Further reading
- Hosokawa Y, Suzuki H, Toda H, et al. (1990). "The primary structure of the precursor to core protein II, a putative member of mitochondrial processing protease family, of rat mitochondrial cytochrome bc1 complex deduced from cDNA sequence analysis.". Biochem. Int. 20 (4): 731–7. PMID 2162168.
- Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP).". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection.". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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