UNC45A

From Wikipedia, the free encyclopedia

Unc-45 homolog A (C. elegans)

PDB rendering based on 2dba.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DBA

Identifiers

UNC45A; GC-UNC45; GCUNC-45; GCUNC45; IRO039700; SMAP-1; SMAP1

External IDs

OMIM: 611219 MGI: 2142246 HomoloGene: 32423 GeneCards: UNC45A Gene

Gene Ontology
Molecular function	• Hsp90 protein binding
Cellular component	• nucleus • perinuclear region of cytoplasm
Biological process	• muscle organ development • cell differentiation • chaperone-mediated protein folding
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000140553

ENSMUSG00000030533

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
91.47 – 91.5 Mb

Chr 7:
80.33 – 80.34 Mb

PubMed search

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.^[1]^[2]

References

↑ Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID 12356907.
↑ "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

Bazzaro M, Santillan A, Lin Z et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC 2043524. PMID 17872978.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chadli A, Graham JD, Abel MG et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC 1430258. PMID 16478993.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

PDB gallery

2dba: The solution structure of the tetratrico peptide repeat of human Smooth muscle cell associated protein-1, isoform 2

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