UNC13B
From Wikipedia, the free encyclopedia
| Unc-13 homolog B (C. elegans) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | UNC13B; MUNC13; UNC13; Unc13h2 | ||||||||||||
| External IDs | OMIM: 605836 MGI: 1342278 HomoloGene: 31376 GeneCards: UNC13B Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10497 | 22249 | |||||||||||
| Ensembl | ENSG00000198722 | ENSMUSG00000028456 | |||||||||||
| UniProt | O14795 | Q9Z1N9 | |||||||||||
| RefSeq (mRNA) | NM_006377 | NM_001081413 | |||||||||||
| RefSeq (protein) | NP_006368 | NP_001074882 | |||||||||||
| Location (UCSC) | Chr 9: 35.16 – 35.41 Mb | Chr 4: 43.06 – 43.26 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.[1][2]
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[2]
Interactions
UNC13B has been shown to interact with STX1B,[3] STX1A,[3] RIMS1,[4][5] SPTBN2[6] and DOC2A.[7][8]
References
- ↑ Song Y, Ailenberg M, Silverman M (August 1998). "Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy". Kidney Int 53 (6): 1689–95. doi:10.1046/j.1523-1755.1998.00942.x. PMID 9607201.
- ↑ 2.0 2.1 "Entrez Gene: UNC13B unc-13 homolog B (C. elegans)".
- ↑ 3.0 3.1 Betz, A; Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. (UNITED STATES) 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. ISSN 0021-9258. PMID 8999968.
- ↑ Betz, A; Thakur P, Junge H J, Ashery U, Rhee J S, Scheuss V, Rosenmund C, Rettig J, Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron (United States) 30 (1): 183–96. doi:10.1016/S0896-6273(01)00272-0. ISSN 0896-6273. PMID 11343654.
- ↑ Ohtsuka, Toshihisa; Takao-Rikitsu Etsuko, Inoue Eiji, Inoue Marie, Takeuchi Masakazu, Matsubara Kaho, Deguchi-Tawarada Maki, Satoh Keiko, Morimoto Koji, Nakanishi Hiroyuki, Takai Yoshimi (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". J. Cell Biol. (United States) 158 (3): 577–90. doi:10.1083/jcb.200202083. ISSN 0021-9525. PMC 2173811. PMID 12163476.
- ↑ Sakaguchi, G; Orita S, Naito A, Maeda M, Igarashi H, Sasaki T, Takai Y (July 1998). "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13". Biochem. Biophys. Res. Commun. (UNITED STATES) 248 (3): 846–51. doi:10.1006/bbrc.1998.9067. ISSN 0006-291X. PMID 9704016.
- ↑ Orita, S; Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. (UNITED STATES) 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. ISSN 0021-9258. PMID 9195900.
- ↑ Mochida, S; Orita S, Sakaguchi G, Sasaki T, Takai Y (September 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. ISSN 0027-8424. PMC 21657. PMID 9736751.
Further reading
- Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
- Orita S, Naito A, Sakaguchi G et al. (1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
- Sakaguchi G, Orita S, Naito A et al. (1998). "A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13". Biochem. Biophys. Res. Commun. 248 (3): 846–51. doi:10.1006/bbrc.1998.9067. PMID 9704016.
- Mochida S, Orita S, Sakaguchi G et al. (1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
- Song Y, Ailenberg M, Silverman M (1999). "Human munc13 Is a Diacylglycerol Receptor that Induces Apoptosis and May Contribute to Renal Cell Injury in Hyperglycemia". Mol. Biol. Cell 10 (5): 1609–19. PMC 30485. PMID 10233166.
- Duncan RR, Betz A, Shipston MJ et al. (1999). "Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo". J. Biol. Chem. 274 (39): 27347–50. doi:10.1074/jbc.274.39.27347. PMID 10488064.
- Betz A, Thakur P, Junge HJ et al. (2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron 30 (1): 183–96. doi:10.1016/S0896-6273(01)00272-0. PMID 11343654.
- Schoch S, Castillo PE, Jo T et al. (2002). "RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone". Nature 415 (6869): 321–6. doi:10.1038/415321a. PMID 11797009.
- Ohtsuka T, Takao-Rikitsu E, Inoue E et al. (2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". J. Cell Biol. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811. PMID 12163476.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sheu L, Pasyk EA, Ji J et al. (2003). "Regulation of insulin exocytosis by Munc13-1". J. Biol. Chem. 278 (30): 27556–63. doi:10.1074/jbc.M303203200. PMID 12871971.
- Cheviet S, Coppola T, Haynes LP et al. (2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
- Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Yamamoto K, Ishii E, Sako M et al. (2005). "Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes". J. Med. Genet. 41 (10): 763–7. doi:10.1136/jmg.2004.021121. PMC 1735600. PMID 15466010.
- Speight P, Silverman M (2005). "Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34". Traffic 6 (10): 858–65. doi:10.1111/j.1600-0854.2005.00321.x. PMID 16138900.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.