UCHL3

From Wikipedia, the free encyclopedia
Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

PDB rendering based on 1uch.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsUCHL3; UCH-L3
External IDsOMIM: 603090 MGI: 1355274 HomoloGene: 4377 ChEMBL: 6195 GeneCards: UCHL3 Gene
EC number3.4.19.12
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez734750933
EnsemblENSG00000118939ENSMUSG00000022111
UniProtP15374Q9JKB1
RefSeq (mRNA)NM_001270952NM_016723
RefSeq (protein)NP_001257881NP_057932
Location (UCSC)Chr 13:
76.12 – 76.18 Mb
Chr 14:
101.65 – 101.7 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase isozyme L3 is an enzyme that in humans is encoded by the UCHL3 gene.[1][2]


Interactions

UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.[3][4]

See also

References

  1. Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J (Dec 1989). "The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase". Science 246 (4930): 670–3. doi:10.1126/science.2530630. PMID 2530630. 
  2. "Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)". 
  3. Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW (July 2011). "Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)". FEBS Lett 585 (16): 2568–74. doi:10.1016/j.febslet.2011.06.037. PMID 21762696. 
  4. Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T (October 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochem. Biophys. Res. Commun. 251 (3): 688–92. doi:10.1006/bbrc.1998.9532. PMID 9790970. 

Further reading

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