UBE2D1

Ubiquitin-conjugating enzyme E2D 1
PDB rendering based on 2c4p.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C4P, 2YHO, 3OJ4, 3PTF, 4AP4
Identifiers
Symbols	UBE2D1; E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
External IDs	OMIM: 602961 MGI: 2384911 HomoloGene: 20714 GeneCards: UBE2D1 Gene
EC number	6.3.2.19
Gene Ontology Molecular function • ubiquitin-protein ligase activity • protein binding • ATP binding Cellular component • nucleoplasm • cytoplasm • cytosol Biological process • cell cycle checkpoint • M phase of mitotic cell cycle • mitotic anaphase • negative regulation of transcription from RNA polymerase II promoter • protein polyubiquitination • mitotic cell cycle • toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • ubiquitin-dependent protein catabolic process • mitotic spindle assembly checkpoint • transforming growth factor beta receptor signaling pathway • gene expression • BMP signaling pathway • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • positive regulation of protein ubiquitination • cellular response to stress • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • innate immune response • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of transcription from RNA polymerase II promoter in response to hypoxia • protein K48-linked ubiquitination • cellular response to hypoxia Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7321	216080
Ensembl	ENSG00000072401	ENSMUSG00000019927
UniProt	P51668	P61080
RefSeq (mRNA)	NM_001204880	NM_145420
RefSeq (protein)	NP_001191809	NP_663395
Location (UCSC)	Chr 10: 60.09 – 60.13 Mb	Chr 10: 71.25 – 71.29 Mb
PubMed search
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Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.^[1][2][3]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.^[3]

Interactions

UBE2D1 has been shown to interact with BARD1,^{[4][5][6][7][8][9][10][11]} UBE3A^[12][13] and BRCA1.^{[4][5][6][7][8][9][10][11][14][15]}

References

Further reading

v t e PDB gallery 2c4p: CRYSTAL STRUCTURE OF HUMAN UBIQUITIN-CONJUGATING ENZYME UBCH5A