UBE1L2

From Wikipedia, the free encyclopedia

Ubiquitin-like modifier activating enzyme 6

Identifiers

UBA6; E1-L2; MOP-4; UBE1L2

External IDs

OMIM: 611361 MGI: 1913894 HomoloGene: 10080 GeneCards: UBA6 Gene

Gene Ontology
Molecular function	• protein binding • ATP binding • ligase activity • FAT10 activating enzyme activity
Cellular component	• cytoplasm
Biological process	• ubiquitin-dependent protein catabolic process • protein ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000033178

ENSMUSG00000035898

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
68.48 – 68.57 Mb

Chr 5:
86.11 – 86.17 Mb

PubMed search

Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.^[1]^[2]

References

↑ Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem 282 (32): 23010–4. doi:10.1074/jbc.C700111200. PMID 17580310.
↑ "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhu H, Zhou ZM, Huo R et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai) 36 (3): 227–34. doi:10.1093/abbs/36.3.227. PMID 15202508.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jin J, Li X, Gygi SP, Harper JW (2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging". Nature 447 (7148): 1135–8. doi:10.1038/nature05902. PMID 17597759.
Chiu YH, Sun Q, Chen ZJ (2007). "E1-L2 activates both ubiquitin and FAT10". Mol. Cell 27 (6): 1014–23. doi:10.1016/j.molcel.2007.08.020. PMID 17889673.

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