UBE1L

From Wikipedia, the free encyclopedia

Ubiquitin-like modifier activating enzyme 7

Identifiers

UBA7; D8; UBA1B; UBE1L; UBE2

External IDs

OMIM: 191325 MGI: 1349462 HomoloGene: 2502 GeneCards: UBA7 Gene

Gene Ontology
Molecular function	• ATP binding • ligase activity • ISG15 activating enzyme activity
Cellular component	• cytosol
Biological process	• cellular protein modification process • protein ubiquitination • cytokine-mediated signaling pathway • modification-dependent protein catabolic process • ISG15-protein conjugation • negative regulation of type I interferon production • innate immune response
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000182179

ENSMUSG00000032596

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
49.84 – 49.85 Mb

Chr 9:
107.98 – 107.98 Mb

PubMed search

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.^[1]^[2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.^[2]

References

↑ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
↑ 2.0 2.1 "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading

Carritt B, Kok K, van den Berg A, et al. (1992). "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer.". Cancer Res. 52 (6): 1536–41. PMID 1311632.
Kok K, Van den Berg A, Veldhuis PM, et al. (1995). "The genomic structure of the human UBE1L gene.". Gene Expr. 4 (3): 163–75. PMID 7734949.
McLaughlin PM, Helfrich W, Kok K, et al. (2000). "The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.". Int. J. Cancer 85 (6): 871–6. doi:10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O. PMID 10709110.
Yuan W, Krug RM (2001). "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein.". EMBO J. 20 (3): 362–71. doi:10.1093/emboj/20.3.362. PMC 133459. PMID 11157743.
Kitareewan S, Pitha-Rowe I, Sekula D, et al. (2002). "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3806–11. doi:10.1073/pnas.052011299. PMC 122605. PMID 11891284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Pitha-Rowe I, Hassel BA, Dmitrovsky E (2004). "Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.". J. Biol. Chem. 279 (18): 18178–87. doi:10.1074/jbc.M309259200. PMID 14976209.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lenschow DJ, Giannakopoulos NV, Gunn LJ, et al. (2006). "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.". J. Virol. 79 (22): 13974–83. doi:10.1128/JVI.79.22.13974-13983.2005. PMC 1280211. PMID 16254333.
Takeuchi T, Iwahara S, Saeki Y, et al. (2005). "Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme.". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.

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