UBE1DC1

From Wikipedia, the free encyclopedia

Ubiquitin-like modifier activating enzyme 5

Rendering based on PDB 3GUC.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3GUC, 3H8V

Identifiers

UBA5; THIFP1; UBE1DC1

External IDs

OMIM: 610552 MGI: 1913913 HomoloGene: 11738 GeneCards: UBA5 Gene

Gene Ontology
Molecular function	• protein binding • ATP binding • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • metal ion binding • cofactor binding • UFM1 activating enzyme activity
Cellular component	• nucleus • cytoplasm • aggresome • intracellular membrane-bounded organelle
Biological process	• protein ufmylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000081307

ENSMUSG00000032557

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
132.37 – 132.4 Mb

Chr 9:
104.05 – 104.06 Mb

PubMed search

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.^[1]^[2]^[3]

This gene encodes a member of the E1-like activating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[3]

References

↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325. PMID 15071506.
↑ 3.0 3.1 "Entrez Gene: UBE1DC1 ubiquitin-activating enzyme E1-domain containing 1".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Dou T, Gu S, Liu J et al. (2006). "Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1". Mol. Biol. Rep. 32 (4): 265–71. doi:10.1007/s11033-005-4822-y. PMID 16328888.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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