Tumor-infiltrating lymphocytes

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Micrograph showing tumor infiltrating lymphocytes in a case of colorectal cancer. H&E stain.

Tumor-infiltrating lymphocytes, also tumour infiltrating lymphocytes, are white blood cells that have left the bloodstream and migrated into a tumor. They are usually abbreviated TILs. When numerous, TILs are considered to be prognostically significant.

Colorectal cancer

In colorectal cancer, they are associated with microsatellite instability cancers, as may be seen in Lynch syndrome.[1]

When TILs are present the lymphocytes are found between the tumor cells; cells in the stroma surrounding the tumor cells do not count.[2] It should be noted that histologic definitions for TILs vary.

Melanoma

They are an important prognostic factor in melanoma and higher levels being associated with a better outcome.[3][4]

They are key to an experimental autologous cell therapy (Contego) for metastatic melanoma.[5] Several centres are currently working on TIL melanoma treatment protocol, including the Ella Institute in Sheba Hospital, Israel[6] and Copenhagen University Hospital at Herlev, Denmark [7] [8]

See also

References

  1. ↑ Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260–9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775. 
  2. ↑ Garg, K.; Soslow, RA. (Aug 2009). "Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.". J Clin Pathol 62 (8): 679–84. doi:10.1136/jcp.2009.064949. PMID 19638537. 
  3. ↑ Spatz et al. (2007). "Protective effect of a brisk tumor infiltrating lymphocyte infiltrate in melanoma: An EORTC melanoma group study.". Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 8519. 
  4. ↑ Galon et al. (2006). "Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome.". Science 29 September 2006: 313 (5795), 1960-1964. 
  5. ↑ "Genesis Biopharma expands clinical focus to develop Contego for Stage IV metastatic melanoma". June 2011. 
  6. ↑ "Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients.". 
  7. ↑ "Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients.". 
  8. ↑ "Methods to Improve Adoptive T-Cell Therapy for Melanoma: IFN-γ Enhances Anticancer Responses of Cell Products for Infusion". 

External links

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".


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