Tryptophan tryptophylquinone

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Tryptophan tryptophylquinone
IUPAC name

2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid

Identifiers
CAS number 134645-25-3
PubChem 5486829
MeSH Tryptophan+tryptophylquinone
Jmol-3D images Image 1
Properties
Molecular formula C22H20N4O6
Molar mass 436.419
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Tryptophan tryptophylquinone(TTQ) is an enzyme cofactor, generated by post-translationational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function.[1]

See also

General
N terminus
C terminus
Single specific AAs
Aspartate
Glutamate
  • Transglutamination
  • C-mannosylation
Crosslinks between two AAs
  • Sulfilimine bond
Lysine-Tyrosylquinone
  • Lysine tyrosylquinone (LTQ) formation
Tryptophan-Tryptophylquinone
Three consecutive AAs
(chromophore formation)
  • p-Hydroxybenzylidene-imidazolinone formation
Crosslinks between four AAs

References

  1. ↑ Davidson VL, Liu A: Uncovering novel biochemistry in the mechanism of tryptophan tryptophylquinone cofactor biosynthesis Curr. Op. Chem. Biol. 2009, 13: 469-474


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