Tropheryma whipplei
| Tropheryma whipplei | |
|---|---|
| Scientific classification | |
| Kingdom: | Bacteria |
| Phylum: | Actinobacteria |
| Class: | Actinobacteria |
| Subclass: | Actinobacteridae |
| Order: | Actinomycetales |
| Family: | Cellulomonadaceae |
| Genus: | Tropheryma |
| Species: | T. whipplei |
| Binomial name | |
| Tropheryma whipplei La Scola et al. 2001 | |
Tropheryma whipplei, formerly called Tropheryma whippelii,[1] is a bacterium and the causative organism of Whipple's disease.[2]
While T. whipplei is categorized with the Gram-positive Actinobacteria, the organism is commonly found to be Gram-negative or Gram-indeterminate when stained in the laboratory.[2] Whipple himself probably observed the organisms as rod-shaped structures with silver stain in his original case.[3]
History of the name
No name was given to the organism until 1991 when the name Tropheryma[4] whippelii was proposed after sections of the bacterial genome were sequenced.[5] The name was changed to Tropheryma whipplei in 2001 (correcting the spelling of Whipple's name) when the organism was deposited in bacterial collections.[2]
Pathogenesis
- Main article: Whipple's disease
References
- ↑ Liang Z, La Scola B, Raoult D (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. Diagn. Lab. Immunol. 9 (1): 156–9. doi:10.1128/CDLI.9.1.156-159.2002. PMC 119894. PMID 11777846.
- ↑ 2.0 2.1 2.2 La Scola B, Fenollar F, Fournier PE, Altwegg M, Mallet MN, Raoult D (July 2001). "Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple's disease bacillus". Int. J. Syst. Evol. Microbiol. 51 (Pt 4): 1471–9. PMID 11491348.
- ↑ Whipple GH. (1907). "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues". Johns Hopkins Hosp Bull 18: 382–91.
- ↑ From Greek τροφή trophê, "nourishment, food" and ἔρυμα eruma, "fence, a defence against, barrier".
- ↑ Relman D, Schmidt T, MacDermott R, Falkow S (1992). "Identification of the uncultured bacillus of Whipple's disease". N Engl J Med 327 (5): 293–301. doi:10.1056/NEJM199207303270501. PMID 1377787.
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