Tripeptidyl peptidase II
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| Tripeptidyl peptidase II | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TPP2; TPP-2 | ||||||||||||
| External IDs | OMIM: 190470 MGI: 102724 HomoloGene: 2471 ChEMBL: 6156 GeneCards: TPP2 Gene | ||||||||||||
| EC number | 3.4.14.10 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7174 | 22019 | |||||||||||
| Ensembl | ENSG00000134900 | ENSMUSG00000041763 | |||||||||||
| UniProt | P29144 | Q64514 | |||||||||||
| RefSeq (mRNA) | NM_003291 | NM_009418 | |||||||||||
| RefSeq (protein) | NP_003282 | NP_033444 | |||||||||||
| Location (UCSC) | Chr 13: 103.25 – 103.33 Mb | Chr 1: 43.93 – 44 Mb | |||||||||||
| PubMed search | |||||||||||||
Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene.[1][2] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[3]
References
- ↑ Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry 30 (1): 168–74. doi:10.1021/bi00215a025. PMID 1670990.
- ↑ "Entrez Gene: TPP2 tripeptidyl peptidase II".
- ↑ Reits E, Neijssen J, Herberts C et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID 15084277.
External links
Further reading
- Tomkinson B, Zetterqvist O (1990). "Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin". Biochem. J. 267 (1): 149–54. PMC 1131257. PMID 1691635.
- Tomkinson B (1992). "Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II". Biomed. Biochim. Acta 50 (4–6): 727–9. PMID 1840501.
- Tomkinson B, Wernstedt C, Hellman U, Zetterqvist O (1987). "Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7508–12. doi:10.1073/pnas.84.21.7508. PMC 299325. PMID 3313395.
- Wilson C, Gibson AM, McDermott JR (1993). "Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain". Neurochem. Res. 18 (7): 743–9. doi:10.1007/BF00966768. PMID 8396212.
- Martinsson T, Vujic M, Tomkinson B (1993). "Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids". Genomics 17 (2): 493–495. doi:10.1006/geno.1993.1353. PMID 8406500.
- Rose C, Vargas F, Facchinetti P et al. (1996). "Characterization and inhibition of a cholecystokinin-inactivating serine peptidase". Nature 380 (6573): 403–9. doi:10.1038/380403a0. PMID 8602240.
- Geier E, Pfeifer G, Wilm M et al. (1999). "A giant protease with potential to substitute for some functions of the proteasome". Science 283 (5404): 978–81. doi:10.1126/science.283.5404.978. PMID 9974389.
- Ganellin CR, Bishop PB, Bambal RB et al. (2000). "Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors". J. Med. Chem. 43 (4): 664–74. doi:10.1021/jm990226g. PMID 10691692.
- Lévy F, Burri L, Morel S et al. (2002). "The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases". J. Immunol. 169 (8): 4161–71. PMID 12370345.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lindås AC, Tomkinson B (2005). "Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II". Gene 345 (2): 249–257. doi:10.1016/j.gene.2004.11.042. PMID 15716107.
- Stavropoulou V, Vasquez V, Cereser B et al. (2006). "TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints". Biochem. Biophys. Res. Commun. 346 (2): 415–25. doi:10.1016/j.bbrc.2006.05.141. PMID 16762321.
- York IA, Bhutani N, Zendzian S et al. (2006). "Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation". J. Immunol. 177 (3): 1434–43. PMID 16849449.
- Lindås AC, Tomkinson B (2007). "Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements". Gene 393 (1–2): 62–69. doi:10.1016/j.gene.2007.01.015. PMID 17343995.
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