Transfusion hemosiderosis

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Transfusion hemosiderosis
Classification and external resources
ICD-10 T80.8
ICD-9 999.8

Transfusional hemosiderosis is the accumulation of iron in the liver and/or heart but also endocrine organs, in patients who receive frequent blood transfusions (such as those with thalassemia, sickle cell disease, aplastic anemia or myelodysplastic syndrome).

Treatment

Treatment is by phlebotomy if anemia is no more an issue, or iron chelating agents: deferoxamine,[1] deferiprone or deferasirox. If iron overload has caused end-organ damage, this is generally irreversible and may require transplantation.

Notable patients

Ted DeVita died of transfusional iron overload from too many blood transfusions.

See also

References

  1. ↑ Cappellini MD (June 2007). "Exjade(R) (deferasirox, ICL670) in the treatment of chronic iron overload associated with blood transfusion". Ther Clin Risk Manag 3 (2): 291–9. doi:10.2147/tcrm.2007.3.2.291. PMC 1936310. PMID 18360637. 

2. Lu JP, Hayashi K. Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol Int. 1994 Mar;44(3):194-9.PubMed PMID: 8025661.

Complications of surgical and medical care (T80–T88, 996–999)
Transfusion reactions
Vaccine injury
Other
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