Thymidine triphosphate

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Thymidine triphosphate

IUPAC name [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Other names dTTP, 2'-deoxythymidine triphosphate
Identifiers
CAS number	365-08-2^N=
PubChem	64968
ChemSpider	58493^N=
MeSH	'-triphosphate thymidine+5'-triphosphate
ChEMBL	CHEMBL363559^N
Jmol-3D images	Image 1
SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
Properties
Molecular formula	C₁₀H₁₇N₂O₁₄P₃
Molar mass	482.168
N Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the "deoxy" prefix in its name.^[1] The corresponding ribonucleoside triphosphate is called 5-methyluridine triphosphate.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References

↑ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

Nucleic acid constituents

Nucleobase

Nucleoside

Ribonucleoside	Adenosine Guanosine 5-Methyluridine Uridine Cytidine Inosine Xanthosine

Deoxyribonucleoside	Deoxyadenosine Deoxyguanosine Thymidine Deoxyuridine Deoxycytidine Deoxyinosine Deoxyxanthosine

Nucleotide
(Nucleoside monophosphate)

Ribonucleotide	AMP GMP m⁵UMP UMP CMP IMP XMP

Deoxyribonucleotide	dAMP dGMP dTMP dUMP dCMP dIMP dXMP

Cyclic nucleotide	cAMP cGMP c-di-GMP cADPR

Nucleoside diphosphate

ADP GDP m⁵UDP UDP CDP

dADP dGDP dTDP dUDP dCDP

Nucleoside triphosphate

ATP GTP m⁵UTP UTP CTP ITP XTP

dATP dGTP dTTP dUTP dCTP dITP dXTP

Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
nucleic acids
- constituents / intermediates
proteins
- Amino acids / intermediates
tetrapyrroles / intermediates

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