Thomson (unit)

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thomson
Unit of Mass-to-charge ratio
Symbol Th
Named after J. J. Thomson

The thomson (symbol: Th) is a unit that has appeared infrequently in scientific literature relating to the field of mass spectrometry as a unit of mass-to-charge ratio. The unit was proposed by Cooks and Rockwood[1] naming it in honour of J. J. Thomson who measured the mass-to-charge ratio of electrons and ions.

Definition

The thomson is defined as[2]

1~{\mathrm {Th}}=1~{\frac {{\mathrm {u}}}{e}}=1~{\frac {{\mathrm {Da}}}{e}}=1.036426\times 10^{{-8}}\,kg\,C^{{-1}}

where u represents the unified atomic mass unit, Da represents the unit dalton, and e represents the elementary charge which is the electric charge unit in the atomic unit system.

For example, for the ion C7H72+ has an exact mass of 91.0 Da. Its charge number is +2, and hence its charge is 2e. The ion will be observed at 45.5 Th in a mass spectrum.

The thomson allows for negative values for negatively charged ions. For example, the benzoate anion would be observed at m/z 121, but at −121 Th since the charge is −e.

Use

The thomson has been used by some mass spectrometrists, for example Alexander Makarov—the inventor of the Orbitrap—in a scientific poster,[3] papers,[4][5] and (notably) one book.[2] The journal Rapid Communications in Mass Spectrometry (in which the original article appeared) states that "the Thomson (Th) may be used for such purposes as a unit of mass-to-charge ratio although it is not currently approved by IUPAP or IUPAC."[6] Even so, the term has been called "controversial" by RCM's former Editor-in Chief[7] (in a review the Hoffman text cited above[2]). The book, Mass Spectrometry Desk Reference, argues against the use of the thomson.[8] However, the editor-in-chief of the Journal of the Mass Spectrometry Society of Japan has written an editorial in support of the thomson unit.[9]

The thomson is not an SI unit, nor has it been defined by IUPAC.

References

  1. ↑ Cooks, R. G.; A. L. Rockwood (1991). "The 'Thomson'. A suggested unit for mass spectroscopists". Rapid Communications in Mass Spectrometry 5 (2): 93. 
  2. ↑ 2.0 2.1 2.2 Stroobant, Vincent; Hoffmann, Edmond de; Charette, Jean Joseph (1996). Mass spectrometry: principles and applications. New York: Wiley. ISBN 0-471-96696-7. 
  3. ↑ The Orbitrap: a novel high-performance electrostatic trap (ASMS)
  4. ↑ Pakenham G, Lango J, Buonarati M, Morin D, Buckpitt A (2002). "Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation". Drug Metab. Dispos. 30 (3): 247–53. doi:10.1124/dmd.30.3.247. PMID 11854141. 
  5. ↑ Mengel-Jørgensen J, Kirpekar F (2002). "Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry". Nucleic Acids Res. 30 (23): e135. doi:10.1093/nar/gnf135. PMC 137990. PMID 12466567. 
  6. ↑ "Rapid Communications in Mass Spectrometry Instructions to Authors". Wiley Interscience. Retrieved 2007-12-03. 
  7. ↑ Boyd, Robert K. (4 December 1998). "Book Review: Mass Spectrometry: Principles and Applications. E. de Hoffman, J. Charette and W. Stroobant. Wiley, Chichester 1996. ISBN 0-471-96697-5". Rapid Communications in Mass Spectrometry 11 (8): 948. doi:10.1002/(SICI)1097-0231(199705)11:8<948::AID-RCM2033>3.0.CO;2-I. 
  8. ↑ Sparkman, O. David (2000). Mass spectrometry desk reference. Pittsburgh: Global View Pub. ISBN 0-9660813-2-3. 
  9. ↑ Yoshino, Ken-Ichi (2007). "Comments on Abscissa Labeling of Mass Spectra". Journal of the Mass Spectrometry Society of Japan 55 (1): 51–61. doi:10.5702/massspec.55.51. Retrieved 2007-12-05. 
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