Thiorphan

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Thiorphan
Systematic (IUPAC) name
(±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
Clinical data
Legal status ?
Identifiers
CAS number 76721-89-6 N
ATC code ?
PubChem CID 3132
DrugBank DB08626
ChemSpider 3020 YesY
ChEMBL CHEMBL10247 YesY
Chemical data
Formula C12H15NO3S 
Mol. mass 253.32 g/mol
 N (what is this?)  (verify)

Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1]

See also

References

  1. ↑ 1.0 1.1 Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640. 
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
Rehydration
Intestinal anti-infectives
Intestinal adsorbents
Antipropulsives (opioids)
Intestinal anti-inflammatory agents
Antidiarrheal micro-organisms
Other antidiarrheals

M: DIG

anat (t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug (A2A/2B/3/4/5/6/7/14/16), blte


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