Thelephoric acid

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Thelephoric acid

Thelephoric acid is a terphenylquinone pigment which is found in several fungi, such as Clitocybe subilludens[1] and Polyozellus multiplex.[2] Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[3]

References

  1. ↑ Sullivan G, Garrett RD, Lenehan RF. (1971). "Occurrence of atromentin and thelephoric acid in cultures of Clitocybe subilludens". Journal of Pharmaceutical Sciences 60 (11): 1727–29. doi:10.1002/jps.2600601134. PMID 4332377. 
  2. ↑ Ju-Yeon K, Rhee I-K, Lee K-B, Hwang J-S, Yoo I-D, Song K-S. (1999). "Thelephoric acid and kynapcin-9 in mushroom Polyozellus multiflex inhibit prolyl endopeptidase in vitro". Journal of Microbiology and Biotechnology 9 (6): 798–803. 
  3. ↑ Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. doi:10.7164/antibiotics.50.773. PMID 9360624. 
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