Terodiline

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Terodiline

Systematic (IUPAC) name
N-tert-butyl-4,4-di(phenyl)butan-2-amine
Clinical data
Legal status	?
Identifiers

ATC code	G04BD05
PubChem	CID 23480
ChemSpider	21952^Y
UNII	70KG06964W^Y
ChEMBL	CHEMBL363295^Y
Chemical data
Formula	C₂₀H₂₇N
Mol. mass	281.435 g/mol
SMILES c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
InChI InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3^Y Key:UISARWKNNNHPGI-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.^[1]

References

↑ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA. "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence".

Urologicals, including antispasmodics (G04B)

Acidifiers

Urinary antispasmodics
(primarily antimuscarinics)

Other urologicals

Urea analogues: Acetohydroxamic acid
Salicylhydroxamic acid

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte

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