Tenuazonic acid
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| Tenuazonic acid | ||
|---|---|---|
 | ||
| Other names 5S,6S-3-acetyl-5-sec-butyl-4-hydroxypyrrolidone-2,4-dione | ||
| Identifiers | ||
| CAS number | 610-88-8  | |
| PubChem | 101949 | |
| ChEMBL | CHEMBL511015  | |
| Jmol-3D images | Image 1 | |
| ||
| Properties | ||
| Molecular formula | C10H15NO3 | |
| Molar mass | 197.231 | |
| Appearance | colorless, oily substance | |
| Acidity (pKa) | 3.5 | |
| Pharmacology | ||
| Routes of administration |
Ingested or Inhaled | |
| Legal status | ||
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Tenuazonic acid is a mycotoxin. It is a toxic secondary metabolite, produced by Alternaria (e. g. Alternaria alternata or Alternaria tenuis) and Phoma species.[1] It inhibits the protein synthesis machinery.[2]
Tenuazonic acid or 5S,6S-3-acetyl-5-sec-butyl-4-hydroxypyrrolidone-2,4-dione[3] is a colorless oil, soluble in chloroform and methanol.[4]
In 1991 Tenuazonic acid was reported to inhibit skin tumor promotion in mice [5]
References
- ↑ Alisa D. Hocking (Editor), John I. Pitt (Editor) and Robert A. Samson (Editor): Advances in Food Mycology. Springer 2006; ISBN 978-0-387-28385-2; p. 23
- ↑ Dilip K. Arora and Arora K. Arora: Fungal Biotechnology in Agricultural, Food, and Environmental Applications. Marcel Dekker Inc; illustrated edition 2003; ISBN 978-0-8247-4770-1; p. 336
- ↑ N. Magan (editor) and M. Olsen (editor): Mycotoxins in Food: Detection and Control. Woodhead Publishing Ltd 2004; ISBN 978-1-85573-733-4, p. 408
- ↑ J. D. Bewley (edi.), M. Black (edi.) and P. Halmer (edi.): The Encyclopedia of Seeds: Science, Technology and Uses. Cab Intl 2006; ISBN 978-0-85199-723-0; p. 438
- ↑ Tenuazonic acid page from Fermentek
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