Telomestatin
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| Telomestatin | ||
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| Identifiers | ||
| CAS number | 265114-54-3  | |
| PubChem | 11954679 | |
| ChEMBL | CHEMBL443683  | |
| Jmol-3D images | {{#if:CC1=C(C2=NC(C3=NC(C4=NC(C5=NC(C6=NC(C7=NC(C8=N[C@@]9([H])CS8)=CO7)=CO6)=CO5)=CO4)=CO3)=C(C)O2)N=C9O1|Image 1 | |
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| Properties | ||
| Molecular formula | C26H14N8O7S | |
| Molar mass | 582.50 g mol−1 | |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells.[1] It was first isolated from the bacteria Streptomyces anulatus.[1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
References
- ↑ 1.0 1.1 Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo (2001). "Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus". Journal of the American Chemical Society 123 (6): 1262–1263. doi:10.1021/ja005780q. PMID 11456694.
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