Technetium (99mTc) exametazime
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|---|---|
| Systematic (IUPAC) name | |
| [[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc) | |
| Clinical data | |
| Licence data | US FDA:link |
| Pregnancy cat. | C (US) |
| Legal status | ℞-only (US) |
| Routes | Intravenous |
| Identifiers | |
| CAS number | 100551-63-1 (exametazime) |
| ATC code | V09AA01 V09HA02 (labelled leucocytes) |
| PubChem | CID 9552069 |
| Chemical data | |
| Formula | C13H25N4O3Tc |
| Mol. mass | 384.3655 g/mol |
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Technetium (99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to by its chemical name of hexamethylpropyleneamine oxime or HMPAO.
Chemistry
Exametazime (hexamethylpropyleneamine oxime, HMPAO)
The drug consists of two of the three stereoisomers of hexametazime (HMPAO), one of which is shown here, the other being its enantiomer.[4] The third stereoisomer is the meso form. Exametazime acts as a chelating agent for the radioisotope technetium-99m.
References
- ↑ Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.
- ↑ Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.
- ↑ Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.
- ↑ Monography in the European Pharmacopoeia
External links
- European Association of Nuclear Medicine: Ceretec
- GE Healthcare: Ceretec
- Exametazime ligand: PubChem 9552071
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