Taliglucerase alfa, commercially known as
Elelyso, is a plant-derived enzyme developed by Protalix and
Pfizer.
[1] The enzyme is a recombinant
glucocerebrosidase used to treat
Gaucher’s Disease and is the first plant-made pharmaceutical to win approval by the U.S. Food and Drug Administration.
[2][3] Expression of proteins in plant cell culture is highly efficient, does not require post-expression modification of the protein, and is not susceptible to contamination by agents such as viruses that are pathological to humans.
[4] Using transgenic carrot cells produces a lower cost alternative, and preclinical studies show that the enzyme was well tolerated by patients.
[5]
See also
References
- ↑ http://clinicaltrials.gov/ct2/show/NCT00962260
- ↑ http://www.sciencemag.org/content/320/5875/473.summary
- ↑ Maxmen, Amy (2 may 2012) First plant-made drug on the market Nature, Biology & Biotechnology, Industry, Retrieved 26 June 2012
- ↑ http://www.gaucherdisease.org/protalix_drug_information.php
- ↑ Aviezer, D; Brill-Almon, E; Shaaltiel, Y; Hashmueli, S; Bartfeld, D; Mizrachi, S; Liberman, Y; Freeman, A et al. (2009). "A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation". In Ho, Paulo Lee. PLoS ONE 4 (3): e4792. doi:10.1371/journal.pone.0004792. PMC 2652073. PMID 19277123.
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| Amino acids and derivatives | |
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| Enzymes | |
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| Various alimentary tract and metabolism products | |
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